Comparative study of protective effects of chitin, chitosan, and N-acetyl chitohexaose against Pseudomonas aeruginosa and Listeria monocytogenes infections in mice

Yoshio Okawa, Makiko Kobayashi, Shigeo Suzuki, Masuko Suzuki

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

We conducted a comparative study of the protective effects of chitin, chitosan, and N-acctyl chitohexaose (NACOS-6) against mice infected intravenously or intraperitoneally with Pseudomonas aeruginosa and Listeria monocytogenes, Mice pretreated with chitin, chitosan, and NACOS-6 showed resistance to intraperitoneal infections by both microbes. Only mice pretreated with chitin and chitosan showed resistance to intravenous infections by both microbes. The number, active oxygen generation, and myeloperoxidase activity of peritoneal exudate cells (PEC) in the chitin, chitosan, and NACOS-6-treated mice were greater than those of the untreated mice. Also, these PEC factors from mice pretreated with chitin and chitosan were greater than those from the NACOS-6-treated mice.

Original languageEnglish (US)
Pages (from-to)902-904
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume26
Issue number6
DOIs
StatePublished - Jun 2003

Keywords

  • Chitin
  • Chitosan
  • Listeria monocytogenes
  • N-acetyl chitohexaose (NACOS-6)
  • Protection against infection
  • Pseudomonas aeruginosa

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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