Comparative Transcriptomics in Ebola Makona-Infected Ferrets, Nonhuman Primates, and Humans

Robert W. Cross, Emily Speranza, Viktoriya Borisevich, Steven G. Widen, Thomas G. Wood, Rebecca S. Shim, Ricky D. Adams, Dawn M. Gerhardt, Richard S. Bennett, Anna N. Honko, Joshua C. Johnson, Lisa E. Hensley, Thomas W. Geisbert, John H. Connor

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The domestic ferret is a uniformly lethal model of infection for 3 species of Ebolavirus known to be pathogenic in humans. Reagents to systematically analyze the ferret host response to infection are lacking; however, the recent publication of a draft ferret genome has opened the potential for transcriptional analysis of ferret models of disease. In this work, we present comparative analysis of longitudinally sampled blood taken from ferrets and nonhuman primates infected with lethal doses of the Makona variant of Zaire ebolavirus. Strong induction of proinflammatory and prothrombotic signaling programs were present in both ferrets and nonhuman primates, and both transcriptomes were similar to previously published datasets of fatal cases of human Ebola virus infection.

Original languageEnglish (US)
Pages (from-to)S486-S495
JournalJournal of Infectious Diseases
Volume218
DOIs
StatePublished - Nov 22 2018

Keywords

  • Ebola virus
  • animal model
  • ferret
  • transcriptomics
  • vaccines.

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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