Comparing the effects of progressive and mild intensity treadmill running protocols on neuroprotection of parkinsonian rats

Ziya Fallah Mohammadi, Hossein Falah Mohammadi, Darpan I. Patel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Aims: Parkinson's disease (PD)is characterized by progressive loss of dopamine cells. It is suggested that exercise could be employed as a non-pharmacological approach for reducing the risk of PD incidence. The purpose of this study was to compare the effects of 4-week Mild-intensity (MIEx)and progressive exercise (PEx)protocols on rotational behavior, GFAP, DA, TH, MANF, CDNF and NGF levels in striatum of parkinsonian rats induced by 6-hydroxydopamine. Methods: 42 Wistar male rats were divided into 6 groups including, healthy and PD controls, MIEx, PEx, healthy MIEx, and healthy PEx. MIEx protocol was performed as follows: 5 days a week, 2 sessions a day of 15 min at a speed of 15 m/min. PEx protocol encompassed a training regimen of 5 days a week initiating by 20 min in the first day reaching 50 min on the fifth day and 60 min in the next 3 weeks. PD was induced after training protocol by injection of 6-OHDA into the striatum of rats. For confirming PD, apomorphine rotational test was employed. Key findings: The MIEx protocol did not have any positive impacts on the variables except for CDNF (P < 0.0001). Levels of DA (P < 0.0001)and TH (P = 0.0004)increased significantly after performing PEx protocol. Moreover, PEx protocol considerably reduced rotational behavior of rats (P = 0.0244). Significance: The findings of this research confirm positive effects of PEx in protecting against PD. This progressive training protocol has explicitly shown a neuroprotective effect against PD-inducing nervous toxin through increasing neurotrophins.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalLife Sciences
StatePublished - Jul 15 2019
Externally publishedYes


  • Cerebral dopamine neurotrophic factor
  • Mesencephalic astrocyte-derived neurotrophic factor
  • Mild-intensity exercise
  • Neurotrophic growth factor
  • Parkinson's disease
  • Progressive exercise

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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