Comparison of a novel liquid (Adcon-P®) and a sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm™) in postsurgical adhesion formation in a murine model

Mustafa Oncel, Feza H. Remzi, Anthony J. Senagore, Jason T. Connor, Victor W. Fazio

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

PURPOSE: Intra-abdominal administration of antiadhesive barriers may reduce the extent and severity of postoperative adhesions. This study aimed to compare the effectiveness of a novel liquid antiadhesive barrier with a conventional sheet (Seprafilm™) antiadhesive barrier in a murine cecal abrasion model. METHODS: One hundred fifty Swiss-Wister mice underwent laparotomy and cecal abrasion and were randomly assigned to receive Adcon-P® (n = 30) or Seprafilm™ (n = 30) or to a control group (n = 90). At postoperative Day 21, the mice underwent relaparotomy and complete adhesiolysis. An investigator who was blinded to the group assignment scored the extent of adhesion formation and the difficulty of adhesiolysis using a 6-point scale that ranged from 0 (no adhesions) to 5 (full-thickness intestinal injury with adhesiolysis). Results are reported as median (range). RESULTS: Median adhesion scores in mice receiving Adcon-P® (0 (range, 0-1)) and Seprafilm™ (1 (range, 0-3)) were lower than in mice in the control group (2 (range, 0-5); P <0.0001 for both comparisons). In addition, the median adhesion score for the Adcon-P® group was significantly lower than that of the Seprafilm™ group (P = 0.02). CONCLUSION: This study suggests that both Adcon-P® and Seprafilm™ decrease the incidence of postoperative adhesions and the difficulty of adhesiolysis in the murine cecal abrasion model. However, Adcon-P® appeared to be superior to Seprafilm™. This agent is an attractive device that requires additional studies.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalDiseases of the Colon and Rectum
Volume46
Issue number2
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

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Carboxymethylcellulose Sodium
Hyaluronic Acid
Membranes
Control Groups
Laparotomy
Adcon-P
Seprafilm
Research Personnel
Equipment and Supplies
Incidence
Wounds and Injuries

Keywords

  • Adcon-P®
  • Adhesiolysis
  • Seprafilm™Postoperative adhesions

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Comparison of a novel liquid (Adcon-P®) and a sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm™) in postsurgical adhesion formation in a murine model. / Oncel, Mustafa; Remzi, Feza H.; Senagore, Anthony J.; Connor, Jason T.; Fazio, Victor W.

In: Diseases of the Colon and Rectum, Vol. 46, No. 2, 01.02.2003, p. 187-191.

Research output: Contribution to journalArticle

Oncel, Mustafa ; Remzi, Feza H. ; Senagore, Anthony J. ; Connor, Jason T. ; Fazio, Victor W. / Comparison of a novel liquid (Adcon-P®) and a sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm™) in postsurgical adhesion formation in a murine model. In: Diseases of the Colon and Rectum. 2003 ; Vol. 46, No. 2. pp. 187-191.
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abstract = "PURPOSE: Intra-abdominal administration of antiadhesive barriers may reduce the extent and severity of postoperative adhesions. This study aimed to compare the effectiveness of a novel liquid antiadhesive barrier with a conventional sheet (Seprafilm™) antiadhesive barrier in a murine cecal abrasion model. METHODS: One hundred fifty Swiss-Wister mice underwent laparotomy and cecal abrasion and were randomly assigned to receive Adcon-P{\circledR} (n = 30) or Seprafilm™ (n = 30) or to a control group (n = 90). At postoperative Day 21, the mice underwent relaparotomy and complete adhesiolysis. An investigator who was blinded to the group assignment scored the extent of adhesion formation and the difficulty of adhesiolysis using a 6-point scale that ranged from 0 (no adhesions) to 5 (full-thickness intestinal injury with adhesiolysis). Results are reported as median (range). RESULTS: Median adhesion scores in mice receiving Adcon-P{\circledR} (0 (range, 0-1)) and Seprafilm™ (1 (range, 0-3)) were lower than in mice in the control group (2 (range, 0-5); P <0.0001 for both comparisons). In addition, the median adhesion score for the Adcon-P{\circledR} group was significantly lower than that of the Seprafilm™ group (P = 0.02). CONCLUSION: This study suggests that both Adcon-P{\circledR} and Seprafilm™ decrease the incidence of postoperative adhesions and the difficulty of adhesiolysis in the murine cecal abrasion model. However, Adcon-P{\circledR} appeared to be superior to Seprafilm™. This agent is an attractive device that requires additional studies.",
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AU - Senagore, Anthony J.

AU - Connor, Jason T.

AU - Fazio, Victor W.

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AB - PURPOSE: Intra-abdominal administration of antiadhesive barriers may reduce the extent and severity of postoperative adhesions. This study aimed to compare the effectiveness of a novel liquid antiadhesive barrier with a conventional sheet (Seprafilm™) antiadhesive barrier in a murine cecal abrasion model. METHODS: One hundred fifty Swiss-Wister mice underwent laparotomy and cecal abrasion and were randomly assigned to receive Adcon-P® (n = 30) or Seprafilm™ (n = 30) or to a control group (n = 90). At postoperative Day 21, the mice underwent relaparotomy and complete adhesiolysis. An investigator who was blinded to the group assignment scored the extent of adhesion formation and the difficulty of adhesiolysis using a 6-point scale that ranged from 0 (no adhesions) to 5 (full-thickness intestinal injury with adhesiolysis). Results are reported as median (range). RESULTS: Median adhesion scores in mice receiving Adcon-P® (0 (range, 0-1)) and Seprafilm™ (1 (range, 0-3)) were lower than in mice in the control group (2 (range, 0-5); P <0.0001 for both comparisons). In addition, the median adhesion score for the Adcon-P® group was significantly lower than that of the Seprafilm™ group (P = 0.02). CONCLUSION: This study suggests that both Adcon-P® and Seprafilm™ decrease the incidence of postoperative adhesions and the difficulty of adhesiolysis in the murine cecal abrasion model. However, Adcon-P® appeared to be superior to Seprafilm™. This agent is an attractive device that requires additional studies.

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