Comparison of Aldactazide and Dyazide for hypertension

Hypokalemia, a common complication of diuretic therapy, is commonly treated by the use of the diuretic combinations Aldactazide and Dyazide. A crossover study was conducted in order to directly compare the blood pressure control and the plasma potassium concentration achieved with these two diuretic combinations. Plasma renin activity responsiveness was categorized with the intravenous furosemide test. There were no significant differences in the blood pressure response, plasma potassium concentration, or frequency of side effects. Renin categorization did not predict diuretic responsiveness and, thus, does not appear to be routinely warranted. Aldactazide and Dyazide appear to be of equal clinical efficacy in the treatment of hypertension.