Comparison of cultured epidermal autograft and massive excision with serial autografting plus homograft overlay

David Herndon, R. L. Rutan

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The chief determinant of mortality in severe burn injuries has been the size and severity of the wound. Early massive excision of the wound has increased the median lethal dose to 98% of total body surface area burn but presents the problem of wound closure. Autograft substitutes must be used for a large burn. We report our experience with early massive excision in the treatment of 47 pediatric patients with burns who had >80% total body surface area burn and >80% full-thickness burn. Four patients died within hours of admission. Fifteen patients died of sepsis and multiorgan failure; the primary source of bacterial contamination was the open wound. The 28 survivors received approximately 2.0 m2 2:1 homograft until autograft became available. A case report of a 10-year-old boy illustrates the use of two types of cultured epidermal autograft, one 'homegrown' and one commercially produced.

Original languageEnglish (US)
Pages (from-to)154-157
Number of pages4
JournalJournal of Burn Care and Rehabilitation
Volume13
Issue number1
StatePublished - 1992

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Autologous Transplantation
Autografts
Allografts
Wounds and Injuries
Body Surface Area
Burns
Survivors
Sepsis
Pediatrics
Mortality

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)

Cite this

Comparison of cultured epidermal autograft and massive excision with serial autografting plus homograft overlay. / Herndon, David; Rutan, R. L.

In: Journal of Burn Care and Rehabilitation, Vol. 13, No. 1, 1992, p. 154-157.

Research output: Contribution to journalArticle

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