Comparison of intraosseous and intravenous delivery of hypertonic saline/dextran in anesthetized, euvolemic pigs

Michael A. Dubick, Juergen W. Pteiffer, Charles B. Clifford, David E. Runyon, George Kramer

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Study objectives: With renewed interest in intraosseous (10) infusion, the present study examined if sternal 10 infusion provided vascular entry of 7.5% NaCI/6% dextran-70 (HSD) as efficiently as IV infusion. Design, setting, type of participants, interventions: Twelve anesthetized pigs were catheterized for measurement of cardiovascular parameters. Six pigs were given a 4-mL/kg 10 infusion of HSD under pressure over two to six minutes; each pig was paired with another that had been given HSD IV over the same time course. Rapid arterial blood sampling was used to evaluate vascular entry of NaCl and dextran with monitoring continued for two hours after infusion. Measurements and main results: Complete vascular entry of infused sodium and dextran was generally complete within one minute after infusion in all experiments. Increases in mean arterial pressure, cardiac output, and other cardiovascular parameters were indistinguishable between 10 and IV infusions. Plasma volume expansion was about 20% above baseline in both groups of pigs. Histologic examination showed minimum pathology to the sternum and no significant pulmonary complications. Conclusion: 10 vascular delivery of HSD is a viable alternative in emergency scenarios in which vascular access is compromised.

Original languageEnglish (US)
Pages (from-to)498-503
Number of pages6
JournalAnnals of Emergency Medicine
Volume21
Issue number5
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

dextran - saline drug combination
Blood Vessels
Swine
Dextrans
Intraosseous Infusions
Sternum
Plasma Volume
Cardiac Output
Arterial Pressure
Emergencies
Sodium
Pathology
Pressure
Lung

Keywords

  • hypertonic saline/dextran
  • intraosseous infusion

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Comparison of intraosseous and intravenous delivery of hypertonic saline/dextran in anesthetized, euvolemic pigs. / Dubick, Michael A.; Pteiffer, Juergen W.; Clifford, Charles B.; Runyon, David E.; Kramer, George.

In: Annals of Emergency Medicine, Vol. 21, No. 5, 1992, p. 498-503.

Research output: Contribution to journalArticle

Dubick, Michael A. ; Pteiffer, Juergen W. ; Clifford, Charles B. ; Runyon, David E. ; Kramer, George. / Comparison of intraosseous and intravenous delivery of hypertonic saline/dextran in anesthetized, euvolemic pigs. In: Annals of Emergency Medicine. 1992 ; Vol. 21, No. 5. pp. 498-503.
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