Comparison of Matrigel and Matriderm as a carrier for human amnion-derived mesenchymal stem cells in wound healing

Alexandru Cristian Tuca; Juliane Ertl; Kerstin Hingerl; Melanie Pichlsberger; Jakob Fuchs; Paul Wurzer; Dagmar Pfeiffer; Vladimir Bubalo; Daryousch Parvizi; Lars Peter Kamolz; Ingrid Lang

doi:10.1016/j.placenta.2016.10.015

Comparison of Matrigel and Matriderm as a carrier for human amnion-derived mesenchymal stem cells in wound healing

Alexandru Cristian Tuca, Juliane Ertl, Kerstin Hingerl, Melanie Pichlsberger, Jakob Fuchs, Paul Wurzer, Dagmar Pfeiffer, Vladimir Bubalo, Daryousch Parvizi, Lars Peter Kamolz, Ingrid Lang

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Amnion-derived mesenchymal stem cells (AMSC) are a promising tool in regenerative medicine. Here we evaluated the utility of Matrigel and Matriderm as carrier for the topical application of AMSC to mice skin wounds. In both application forms, AMSC promoted neovascularization of the wound area. Matrigel proved as excellent matrix for AMSC and immigrating mouse cells, but the solid Matriderm enabled a more adequate positioning of AMSC into the wound. Although AMSC did not attach to Matriderm, they reliably induced wound reduction. Thus, a combined administration of AMSC/Matriderm could be beneficial to potentiate the encouraging effects on wound healing.

Original language	English (US)
Pages (from-to)	99-103
Number of pages	5
Journal	Placenta
Volume	48
DOIs	https://doi.org/10.1016/j.placenta.2016.10.015
State	Published - Dec 1 2016
Externally published	Yes

Keywords

Amnion
Angiogenesis
Human placenta
Mesenchymal stem cells
Mouse model
Wound healing

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology
Developmental Biology

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10.1016/j.placenta.2016.10.015

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title = "Comparison of Matrigel and Matriderm as a carrier for human amnion-derived mesenchymal stem cells in wound healing",

abstract = "Amnion-derived mesenchymal stem cells (AMSC) are a promising tool in regenerative medicine. Here we evaluated the utility of Matrigel and Matriderm as carrier for the topical application of AMSC to mice skin wounds. In both application forms, AMSC promoted neovascularization of the wound area. Matrigel proved as excellent matrix for AMSC and immigrating mouse cells, but the solid Matriderm enabled a more adequate positioning of AMSC into the wound. Although AMSC did not attach to Matriderm, they reliably induced wound reduction. Thus, a combined administration of AMSC/Matriderm could be beneficial to potentiate the encouraging effects on wound healing.",

keywords = "Amnion, Angiogenesis, Human placenta, Mesenchymal stem cells, Mouse model, Wound healing",

author = "Tuca, {Alexandru Cristian} and Juliane Ertl and Kerstin Hingerl and Melanie Pichlsberger and Jakob Fuchs and Paul Wurzer and Dagmar Pfeiffer and Vladimir Bubalo and Daryousch Parvizi and Kamolz, {Lars Peter} and Ingrid Lang",

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AU - Tuca, Alexandru Cristian

AU - Ertl, Juliane

AU - Hingerl, Kerstin

AU - Pichlsberger, Melanie

AU - Fuchs, Jakob

AU - Wurzer, Paul

AU - Pfeiffer, Dagmar

AU - Bubalo, Vladimir

AU - Parvizi, Daryousch

AU - Kamolz, Lars Peter

AU - Lang, Ingrid

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Amnion-derived mesenchymal stem cells (AMSC) are a promising tool in regenerative medicine. Here we evaluated the utility of Matrigel and Matriderm as carrier for the topical application of AMSC to mice skin wounds. In both application forms, AMSC promoted neovascularization of the wound area. Matrigel proved as excellent matrix for AMSC and immigrating mouse cells, but the solid Matriderm enabled a more adequate positioning of AMSC into the wound. Although AMSC did not attach to Matriderm, they reliably induced wound reduction. Thus, a combined administration of AMSC/Matriderm could be beneficial to potentiate the encouraging effects on wound healing.

AB - Amnion-derived mesenchymal stem cells (AMSC) are a promising tool in regenerative medicine. Here we evaluated the utility of Matrigel and Matriderm as carrier for the topical application of AMSC to mice skin wounds. In both application forms, AMSC promoted neovascularization of the wound area. Matrigel proved as excellent matrix for AMSC and immigrating mouse cells, but the solid Matriderm enabled a more adequate positioning of AMSC into the wound. Although AMSC did not attach to Matriderm, they reliably induced wound reduction. Thus, a combined administration of AMSC/Matriderm could be beneficial to potentiate the encouraging effects on wound healing.

KW - Amnion

KW - Angiogenesis

KW - Human placenta

KW - Mesenchymal stem cells

KW - Mouse model

KW - Wound healing

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JO - Placenta

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ER -

Comparison of Matrigel and Matriderm as a carrier for human amnion-derived mesenchymal stem cells in wound healing

Abstract

Keywords

ASJC Scopus subject areas

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