Comparison of Matrigel and Matriderm as a carrier for human amnion-derived mesenchymal stem cells in wound healing

Alexandru Cristian Tuca, Juliane Ertl, Kerstin Hingerl, Melanie Pichlsberger, Jakob Fuchs, Paul Wurzer, Dagmar Pfeiffer, Vladimir Bubalo, Daryousch Parvizi, Lars Peter Kamolz, Ingrid Lang

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Amnion-derived mesenchymal stem cells (AMSC) are a promising tool in regenerative medicine. Here we evaluated the utility of Matrigel and Matriderm as carrier for the topical application of AMSC to mice skin wounds. In both application forms, AMSC promoted neovascularization of the wound area. Matrigel proved as excellent matrix for AMSC and immigrating mouse cells, but the solid Matriderm enabled a more adequate positioning of AMSC into the wound. Although AMSC did not attach to Matriderm, they reliably induced wound reduction. Thus, a combined administration of AMSC/Matriderm could be beneficial to potentiate the encouraging effects on wound healing.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalPlacenta
Volume48
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

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Keywords

  • Amnion
  • Angiogenesis
  • Human placenta
  • Mesenchymal stem cells
  • Mouse model
  • Wound healing

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

Cite this

Tuca, A. C., Ertl, J., Hingerl, K., Pichlsberger, M., Fuchs, J., Wurzer, P., Pfeiffer, D., Bubalo, V., Parvizi, D., Kamolz, L. P., & Lang, I. (2016). Comparison of Matrigel and Matriderm as a carrier for human amnion-derived mesenchymal stem cells in wound healing. Placenta, 48, 99-103. https://doi.org/10.1016/j.placenta.2016.10.015