Comparison of ocular outcomes across two 14-day bed rest platforms

Ronita L. Cromwell, Susana B. Zanello, Patrice O. Yarbough, Giovanni Taibbi, Gianmarco Vizzeri

Research output: Chapter in Book/Report/Conference proceedingConference contribution


One possible mechanism for visual changes reported in astronauts may involve microgravity induced cephalad fluid shifts that lead to elevated retrobulbar cerebrospinal fluid pressure. Because head-down tilt (HDT) bed rest induces cephalad fluid shifts, vision monitoring was implemented for NASA bed rest campaigns. Subjects selected for these campaigns were healthy adults (14 males and 5 females). In one campaign, subjects maintained a horizontal (0°) position while in bed and were exercised six days per week. In the other campaign, subjects were placed at 6° HDT while in bed and did not engage in exercise. Measures common to both studies included intraocular pressure and retinal measures derived from optical coherence tomography. There were no significant differences between subject groups for pre- and post bed rest testing. These preliminary results suggest that exercise combined with horizontal bed rest as compared to 6° HDT bed rest did not produce differences in the ocular response of these subjects. Further investigation is needed to examine both the acute response and long term adaptation of structural and functional ocular parameters in the bed rest platform.

Original languageEnglish (US)
Title of host publicationProceedings of Life in Space for Life on Earth
StatePublished - Dec 1 2013
EventLife in Space for Life on Earth - Aberdeen, United Kingdom
Duration: Jun 18 2012Jun 22 2012

Publication series

NameEuropean Space Agency, (Special Publication) ESA SP
Volume706 SP
ISSN (Print)0379-6566


OtherLife in Space for Life on Earth
Country/TerritoryUnited Kingdom

ASJC Scopus subject areas

  • Aerospace Engineering
  • Space and Planetary Science


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