Comparison of open and minimally invasive surgery for intradural-extramedullary spine tumors

Albert P. Wong, Rishi Rajiv Lall, Nader S. Dahdaleh, Cort D. Lawton, Zachary A. Smith, Ricky H. Wong, Michael J. Harvey, Sandi Lam, Tyler R. Koski, Richard G. Fessler

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Object Patients with symptomatic intradural-extramedullary (ID-EM) tumors may be successfully treated with resection of the lesion and decompression of associated neural structures. Studies of patients undergoing open resection of these tumors have reported high rates of gross-total resection (GTR) with minimal long-term neurological deficit. Case reports and small case series have suggested that these patients may be successfully treated with minimally invasive surgery (MIS). These studies have been limited by small patient populations. Moreover, there are no studies directly comparing perioperative outcomes between patients treated with open resection and MIS. The objective of this study was to compare perioperative outcomes in patients with ID-EM tumors treated using open resection or MIS. Methods A retrospective review was performed using data collected from 45 consecutive patients treated by open resection or MIS for ID-EM spine tumors. These patients were treated over a 9-year period between April 2003 and October 2012 at Northwestern University and the University of Chicago. Statistical analysis was performed to compare perioperative outcomes between the two groups. Results Of the 45 patients in the study, 27 were treated with the MIS approach and 18 were treated with the open approach. Operative time was similar between the two groups: 256.3 minutes in the MIS group versus 241.1 minutes in the open group (p = 0.55). Estimated blood loss was significantly lower in the MIS group (133.7 ml) compared with the open group (558.8 ml) (p < 0.01). A GTR was achieved in 94.4% of the open cases and 92.6% of the MIS cases (p = 0.81). The mean hospital stay was significantly shorter in the MIS group (3.9 days) compared with the open group (6.1 days) (p < 0.01). There was no significant difference between the complication rates (p = 0.32) and reoperation rates (p = 0.33) between the two groups. Multivariate analysis demonstrated an increased rate of complications in cervical spine tumors (OR 15, p = 0.05). Conclusions Thoracolumbar ID-EM tumors may be safely and effectively treated with either the open approach or an MIS approach, with an equivalent rate of GTR, perioperative complication rate, and operative time. Patients treated with an MIS approach may benefit from a decrease in operative blood loss and shorter hospital stays.

Original languageEnglish (US)
Pages (from-to)E11
JournalNeurosurgical focus
Volume39
Issue number2
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Minimally Invasive Surgical Procedures
Spine
Neoplasms
Operative Time
Length of Stay
Decompression
Reoperation
Multivariate Analysis

Keywords

  • Extramedullary tumor
  • Intradural tumor
  • Intradural-extramedullary tumor
  • Minimally invasive surgery
  • Spine surgery
  • Spine tumor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Wong, A. P., Lall, R. R., Dahdaleh, N. S., Lawton, C. D., Smith, Z. A., Wong, R. H., ... Fessler, R. G. (2015). Comparison of open and minimally invasive surgery for intradural-extramedullary spine tumors. Neurosurgical focus, 39(2), E11. https://doi.org/10.3171/2015.5.FOCUS15129

Comparison of open and minimally invasive surgery for intradural-extramedullary spine tumors. / Wong, Albert P.; Lall, Rishi Rajiv; Dahdaleh, Nader S.; Lawton, Cort D.; Smith, Zachary A.; Wong, Ricky H.; Harvey, Michael J.; Lam, Sandi; Koski, Tyler R.; Fessler, Richard G.

In: Neurosurgical focus, Vol. 39, No. 2, 01.01.2015, p. E11.

Research output: Contribution to journalArticle

Wong, AP, Lall, RR, Dahdaleh, NS, Lawton, CD, Smith, ZA, Wong, RH, Harvey, MJ, Lam, S, Koski, TR & Fessler, RG 2015, 'Comparison of open and minimally invasive surgery for intradural-extramedullary spine tumors', Neurosurgical focus, vol. 39, no. 2, pp. E11. https://doi.org/10.3171/2015.5.FOCUS15129
Wong, Albert P. ; Lall, Rishi Rajiv ; Dahdaleh, Nader S. ; Lawton, Cort D. ; Smith, Zachary A. ; Wong, Ricky H. ; Harvey, Michael J. ; Lam, Sandi ; Koski, Tyler R. ; Fessler, Richard G. / Comparison of open and minimally invasive surgery for intradural-extramedullary spine tumors. In: Neurosurgical focus. 2015 ; Vol. 39, No. 2. pp. E11.
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abstract = "Object Patients with symptomatic intradural-extramedullary (ID-EM) tumors may be successfully treated with resection of the lesion and decompression of associated neural structures. Studies of patients undergoing open resection of these tumors have reported high rates of gross-total resection (GTR) with minimal long-term neurological deficit. Case reports and small case series have suggested that these patients may be successfully treated with minimally invasive surgery (MIS). These studies have been limited by small patient populations. Moreover, there are no studies directly comparing perioperative outcomes between patients treated with open resection and MIS. The objective of this study was to compare perioperative outcomes in patients with ID-EM tumors treated using open resection or MIS. Methods A retrospective review was performed using data collected from 45 consecutive patients treated by open resection or MIS for ID-EM spine tumors. These patients were treated over a 9-year period between April 2003 and October 2012 at Northwestern University and the University of Chicago. Statistical analysis was performed to compare perioperative outcomes between the two groups. Results Of the 45 patients in the study, 27 were treated with the MIS approach and 18 were treated with the open approach. Operative time was similar between the two groups: 256.3 minutes in the MIS group versus 241.1 minutes in the open group (p = 0.55). Estimated blood loss was significantly lower in the MIS group (133.7 ml) compared with the open group (558.8 ml) (p < 0.01). A GTR was achieved in 94.4{\%} of the open cases and 92.6{\%} of the MIS cases (p = 0.81). The mean hospital stay was significantly shorter in the MIS group (3.9 days) compared with the open group (6.1 days) (p < 0.01). There was no significant difference between the complication rates (p = 0.32) and reoperation rates (p = 0.33) between the two groups. Multivariate analysis demonstrated an increased rate of complications in cervical spine tumors (OR 15, p = 0.05). Conclusions Thoracolumbar ID-EM tumors may be safely and effectively treated with either the open approach or an MIS approach, with an equivalent rate of GTR, perioperative complication rate, and operative time. Patients treated with an MIS approach may benefit from a decrease in operative blood loss and shorter hospital stays.",
keywords = "Extramedullary tumor, Intradural tumor, Intradural-extramedullary tumor, Minimally invasive surgery, Spine surgery, Spine tumor",
author = "Wong, {Albert P.} and Lall, {Rishi Rajiv} and Dahdaleh, {Nader S.} and Lawton, {Cort D.} and Smith, {Zachary A.} and Wong, {Ricky H.} and Harvey, {Michael J.} and Sandi Lam and Koski, {Tyler R.} and Fessler, {Richard G.}",
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T1 - Comparison of open and minimally invasive surgery for intradural-extramedullary spine tumors

AU - Wong, Albert P.

AU - Lall, Rishi Rajiv

AU - Dahdaleh, Nader S.

AU - Lawton, Cort D.

AU - Smith, Zachary A.

AU - Wong, Ricky H.

AU - Harvey, Michael J.

AU - Lam, Sandi

AU - Koski, Tyler R.

AU - Fessler, Richard G.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Object Patients with symptomatic intradural-extramedullary (ID-EM) tumors may be successfully treated with resection of the lesion and decompression of associated neural structures. Studies of patients undergoing open resection of these tumors have reported high rates of gross-total resection (GTR) with minimal long-term neurological deficit. Case reports and small case series have suggested that these patients may be successfully treated with minimally invasive surgery (MIS). These studies have been limited by small patient populations. Moreover, there are no studies directly comparing perioperative outcomes between patients treated with open resection and MIS. The objective of this study was to compare perioperative outcomes in patients with ID-EM tumors treated using open resection or MIS. Methods A retrospective review was performed using data collected from 45 consecutive patients treated by open resection or MIS for ID-EM spine tumors. These patients were treated over a 9-year period between April 2003 and October 2012 at Northwestern University and the University of Chicago. Statistical analysis was performed to compare perioperative outcomes between the two groups. Results Of the 45 patients in the study, 27 were treated with the MIS approach and 18 were treated with the open approach. Operative time was similar between the two groups: 256.3 minutes in the MIS group versus 241.1 minutes in the open group (p = 0.55). Estimated blood loss was significantly lower in the MIS group (133.7 ml) compared with the open group (558.8 ml) (p < 0.01). A GTR was achieved in 94.4% of the open cases and 92.6% of the MIS cases (p = 0.81). The mean hospital stay was significantly shorter in the MIS group (3.9 days) compared with the open group (6.1 days) (p < 0.01). There was no significant difference between the complication rates (p = 0.32) and reoperation rates (p = 0.33) between the two groups. Multivariate analysis demonstrated an increased rate of complications in cervical spine tumors (OR 15, p = 0.05). Conclusions Thoracolumbar ID-EM tumors may be safely and effectively treated with either the open approach or an MIS approach, with an equivalent rate of GTR, perioperative complication rate, and operative time. Patients treated with an MIS approach may benefit from a decrease in operative blood loss and shorter hospital stays.

AB - Object Patients with symptomatic intradural-extramedullary (ID-EM) tumors may be successfully treated with resection of the lesion and decompression of associated neural structures. Studies of patients undergoing open resection of these tumors have reported high rates of gross-total resection (GTR) with minimal long-term neurological deficit. Case reports and small case series have suggested that these patients may be successfully treated with minimally invasive surgery (MIS). These studies have been limited by small patient populations. Moreover, there are no studies directly comparing perioperative outcomes between patients treated with open resection and MIS. The objective of this study was to compare perioperative outcomes in patients with ID-EM tumors treated using open resection or MIS. Methods A retrospective review was performed using data collected from 45 consecutive patients treated by open resection or MIS for ID-EM spine tumors. These patients were treated over a 9-year period between April 2003 and October 2012 at Northwestern University and the University of Chicago. Statistical analysis was performed to compare perioperative outcomes between the two groups. Results Of the 45 patients in the study, 27 were treated with the MIS approach and 18 were treated with the open approach. Operative time was similar between the two groups: 256.3 minutes in the MIS group versus 241.1 minutes in the open group (p = 0.55). Estimated blood loss was significantly lower in the MIS group (133.7 ml) compared with the open group (558.8 ml) (p < 0.01). A GTR was achieved in 94.4% of the open cases and 92.6% of the MIS cases (p = 0.81). The mean hospital stay was significantly shorter in the MIS group (3.9 days) compared with the open group (6.1 days) (p < 0.01). There was no significant difference between the complication rates (p = 0.32) and reoperation rates (p = 0.33) between the two groups. Multivariate analysis demonstrated an increased rate of complications in cervical spine tumors (OR 15, p = 0.05). Conclusions Thoracolumbar ID-EM tumors may be safely and effectively treated with either the open approach or an MIS approach, with an equivalent rate of GTR, perioperative complication rate, and operative time. Patients treated with an MIS approach may benefit from a decrease in operative blood loss and shorter hospital stays.

KW - Extramedullary tumor

KW - Intradural tumor

KW - Intradural-extramedullary tumor

KW - Minimally invasive surgery

KW - Spine surgery

KW - Spine tumor

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