Comparison of optoacoustic tomography with ultrasound and X-ray imaging for breast cancer detection

K. Larin, O. Hartrumpf, I. Larina, R. Esenaliev

Research output: Contribution to journalConference articlepeer-review

14 Scopus citations


This paper is devoted to comparison new optoacoustic tomography with conventional breast tumors diagnostic techniques such as ultrasonography and X-ray radiography. Experiments were performed in phantoms simulating breast with tumors. The fundamental harmonic of Q-switched Nd:YAG laser (λ = 1064 nm) was used to generate optoacoustic pressure waves. Laser induced pressure waves were detected by a wide-band acoustic transducer. Digital oscilloscope controlled by PC was used to store and process optoacoustic signals. Gelatin phantoms with controlled optical parameters were prepared to simulate breast with tumors. Absorbing volumes colored with naphthol green and hemoglobin were embedded in the gelatin phantoms to model the breast tumors with increased optical absorption. Optoacoustic pressure waves from the phantoms were detected at different angles and 2D images were reconstructed. Comparison of optoacoustic images with images obtained with ultrasound and X-ray techniques proved that optoacoustic method has substantially higher contrast and resolution. Obtained results confirm that laser optoacoustic imaging technique can be an important tool for early breast cancer detection with tumors less than 5 mm in diameter.

Original languageEnglish (US)
Pages (from-to)147-153
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2001
EventBiomedical Optoacoustics II - San Jose, CA, United States
Duration: Jan 23 2001Jan 24 2001


  • Breast cancer
  • Imaging
  • Noninvasive
  • Optoacoustics

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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