Comparison of peripheral and central infusions of 7.5% NaCl/6% dextran 70

Russell Hands, James W. Holcroft, Paul R. Perron, George Kramer

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Although it had been known for several years that central venous injections of hypertonic salt solutions with added dextran could effectively resuscitate animals from hemorrhagic shock, it was not known whether peripheral injections could result in the same beneficial effects. Chronically instrumented, unrestrained, and unanesthetized sheep were subjected to a moderate degree of hemorrhagic shock and then resusciated with a 2-minute infusion of 7.5% NaCl/6% dextran 70 in a volume of 5 ml/kg body weight. Infusions were made into the cephalic vein, the femoral artery, or, centrally, the superior vena cava. All three routes of injection promptly reestablished arterial pressure and cardiac output. All gave equivalently good restoration of plasma volume. None of the injections damaged the vessels, as determined either by gross inspection or by histologic examination. Thus the solution was safe and effective when given peripherally. It might be useful in the field resuscitation of hypovolemic patients.

Original languageEnglish (US)
Pages (from-to)684-689
Number of pages6
JournalSurgery
Volume103
Issue number6
StatePublished - 1988
Externally publishedYes

Fingerprint

Dextrans
Injections
Hemorrhagic Shock
Hypertonic Solutions
Hypovolemia
Superior Vena Cava
Plasma Volume
Femoral Artery
Resuscitation
Cardiac Output
Veins
Sheep
Arterial Pressure
Salts
Head
Body Weight

ASJC Scopus subject areas

  • Surgery

Cite this

Hands, R., Holcroft, J. W., Perron, P. R., & Kramer, G. (1988). Comparison of peripheral and central infusions of 7.5% NaCl/6% dextran 70. Surgery, 103(6), 684-689.

Comparison of peripheral and central infusions of 7.5% NaCl/6% dextran 70. / Hands, Russell; Holcroft, James W.; Perron, Paul R.; Kramer, George.

In: Surgery, Vol. 103, No. 6, 1988, p. 684-689.

Research output: Contribution to journalArticle

Hands, R, Holcroft, JW, Perron, PR & Kramer, G 1988, 'Comparison of peripheral and central infusions of 7.5% NaCl/6% dextran 70', Surgery, vol. 103, no. 6, pp. 684-689.
Hands, Russell ; Holcroft, James W. ; Perron, Paul R. ; Kramer, George. / Comparison of peripheral and central infusions of 7.5% NaCl/6% dextran 70. In: Surgery. 1988 ; Vol. 103, No. 6. pp. 684-689.
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