Comparison of self-reported and monitored compliance of daily injection of human growth hormone in burned children

Judy P. Wilkins, Oscar Suman, Deb A. Benjamin, David Herndon

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives. We compared insulin-like growth factor (IGF-I) levels obtained in two groups with different methods of assessing compliance. Burned children were randomized to receive a daily injection of 0.05-0.1mg/kg per day of recombinant human growth hormone (rhGH) or placebo. Study design. One hundred twenty-five children (age range 6 months to 17 years) with total body surface area burns >40% participated in the study. Baseline levels of IGF-I were obtained at hospital discharge, at which time daily injections of rhGH or placebo were initiated. Assessment of IGF-I levels was repeated at 3-month intervals for 1 year. A directly monitored group met daily with research staff that witnessed the preparation and injection of the study drug. A self-reported group completed a Self Reported Compliance Questionnaire (SRCQ) that assessed compliance with drug regimen. A compliance of at least 85% (injections reported administered/maximal total injections possible) was accepted as being compliant. Data were analyzed using a one-way ANOVA followed by a Student Newman-Kuels test, with the results given as means±S.E.M. Results. The percent change in IGF-I levels between 6 and 9 months in the self-reported (22.7±7.9%) and monitored groups (21.9±8.6%) were similar. In contrast, the percent change in IGF-I levels in the placebo group was significantly decreased (-5.6±6.3%). Conclusions. Self-reported scores via an SRCQ is a potentially useful and valid method of assessing compliance of rhGH injections, as both reported and directly monitored methods yield similar changes in levels of IGF-I.

Original languageEnglish (US)
Pages (from-to)697-701
Number of pages5
JournalBurns
Volume29
Issue number7
DOIs
StatePublished - Nov 2003

Fingerprint

Human Growth Hormone
Insulin-Like Growth Factor I
Compliance
Injections
Growth Hormone
Placebos
Body Surface Area
Burns
Pharmaceutical Preparations
Analysis of Variance
Students
Research

Keywords

  • Burns
  • Children
  • Compliance
  • Growth hormone

ASJC Scopus subject areas

  • Emergency Medicine
  • Surgery

Cite this

Comparison of self-reported and monitored compliance of daily injection of human growth hormone in burned children. / Wilkins, Judy P.; Suman, Oscar; Benjamin, Deb A.; Herndon, David.

In: Burns, Vol. 29, No. 7, 11.2003, p. 697-701.

Research output: Contribution to journalArticle

Wilkins, Judy P. ; Suman, Oscar ; Benjamin, Deb A. ; Herndon, David. / Comparison of self-reported and monitored compliance of daily injection of human growth hormone in burned children. In: Burns. 2003 ; Vol. 29, No. 7. pp. 697-701.
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abstract = "Objectives. We compared insulin-like growth factor (IGF-I) levels obtained in two groups with different methods of assessing compliance. Burned children were randomized to receive a daily injection of 0.05-0.1mg/kg per day of recombinant human growth hormone (rhGH) or placebo. Study design. One hundred twenty-five children (age range 6 months to 17 years) with total body surface area burns >40{\%} participated in the study. Baseline levels of IGF-I were obtained at hospital discharge, at which time daily injections of rhGH or placebo were initiated. Assessment of IGF-I levels was repeated at 3-month intervals for 1 year. A directly monitored group met daily with research staff that witnessed the preparation and injection of the study drug. A self-reported group completed a Self Reported Compliance Questionnaire (SRCQ) that assessed compliance with drug regimen. A compliance of at least 85{\%} (injections reported administered/maximal total injections possible) was accepted as being compliant. Data were analyzed using a one-way ANOVA followed by a Student Newman-Kuels test, with the results given as means±S.E.M. Results. The percent change in IGF-I levels between 6 and 9 months in the self-reported (22.7±7.9{\%}) and monitored groups (21.9±8.6{\%}) were similar. In contrast, the percent change in IGF-I levels in the placebo group was significantly decreased (-5.6±6.3{\%}). Conclusions. Self-reported scores via an SRCQ is a potentially useful and valid method of assessing compliance of rhGH injections, as both reported and directly monitored methods yield similar changes in levels of IGF-I.",
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