Comparison of surgical versus transcatheter aortic valve replacement for patients with aortic stenosis at low-intermediate risk

Mahin R. Khan, Waleed T. Kayani, Malalai Manan, Ahmad Munir, Ihab Hamzeh, Salim S. Virani, Yochai Birnbaum, Hani Jneid, Mahboob Alam

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: To compare safety and efficacy of transcatheter aortic valve replacement (TAVR) with surgical aortic valve replacement (SAVR) in patients at low-intermediate risk, given the paucity of robust data. Methods: We performed an aggregate data meta-analysis of 7 randomized controlled trials (RCTs) and 6,778 patients comparing TAVR with SAVR for aortic stenosis (AS) in low-intermediate risk patients (Society of Thoracic Surgeons risk-score ≤8%) using the random-effects model. Primary outcome was all-cause mortality at 30-day, 1-year and 2-year of follow-up. Secondary outcomes included cardiac-mortality, stroke, acute kidney injury (AKI), atrial fibrillation (AF), permanent pacemaker (PPM) implantation, major-bleeding, moderate-severe paravalvular regurgitation (PVR) and rehospitalization. Results: All-cause mortality, cardiac-mortality and stroke were comparable between the two groups. AF was higher with SAVR at 30-day [odds ratio (OR) 0.17, 95% confidence intervals (CI): 0.12-0.24] thorough to 2-year (OR 0.34, 95% CI: 0.21-0.55), while PPM implantation was higher with TAVR (30-day: OR 3.31, 95% CI: 1.64-6.66, 2-year: OR 3.17, 95% CI: 1.02-9.86). Moderate-severe PVR was more prevalent with TAVR at all follow-ups. On inter-group comparison, patients in the low-risk group had an even lower risk of AF, but a higher risk of PPM implantation as compared to the patients in the intermediate-risk group undergoing TAVR. Conclusions: Compared to SAVR, TAVR had comparable all-cause mortality and stroke, lower-risk of AF, but was associated with a higher risk of PPM implantation and moderate-severe PVR in low-intermediate-risk patients. Thus, highlighting the need for longer-term follow-up before robust inferences are drawn.

Original languageEnglish (US)
Pages (from-to)135-144
Number of pages10
JournalCardiovascular Diagnosis and Therapy
Issue number2
StatePublished - Apr 1 2020
Externally publishedYes


  • Low-intermediate risk
  • Surgical aortic valve replacement (SAVR)
  • Transcatheter aortic valve replacement (TAVR)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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