Comparison of symptoms of influenza A with abacavir-associated hypersensitivity reaction

Philip Keiser, Naiel Nassar, Daniel Skiest, Charla Andrews, Beena Yazdani, Alice White, Seth Hetherington

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Differentiation between abacavir hypersensitivity and viral respiratory infections is problematic. Fifteen cases of abacavir hypersensitivity were matched to 30 controls with culture proven influenza A with no abacavir exposure. Rash was associated with hypersensitivity (odds ratio [OR]=13.1, P=0.02) as was the presence of nausea (OR=30, P<0.001), vomiting (OR=17.1, P=0.001) or diarrhoea (OR=22, P<0.001). The number of gastrointestinal symptoms was also predictive of hypersensitivity reaction (P<0.001). Respiratory symptoms (cough, sore throat, or dyspnoea) were not associated with abacavir hypersensitivity (OR=0.08, P=0.001). Multivariate analysis confirmed the following associations for abacavir hypersensitivity: the number of gastrointestinal symptoms (OR=8.6, P=0.0032), cough (OR=0.039, P=0.02) and rash (OR=16.9, P=0.07). Abacavir hypersensitivity is strongly associated with gastrointestinal (GI) symptoms. Cough without GI symptoms is associated with influenza.

Original languageEnglish (US)
Pages (from-to)478-481
Number of pages4
JournalInternational Journal of STD and AIDS
Volume14
Issue number7
DOIs
StatePublished - Jul 1 2003

Keywords

  • Allergy
  • Antiretroviral therapy
  • Hypersensitivity
  • Influenza

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

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