Abstract
Differentiation between abacavir hypersensitivity and viral respiratory infections is problematic. Fifteen cases of abacavir hypersensitivity were matched to 30 controls with culture proven influenza A with no abacavir exposure. Rash was associated with hypersensitivity (odds ratio [OR]=13.1, P=0.02) as was the presence of nausea (OR=30, P<0.001), vomiting (OR=17.1, P=0.001) or diarrhoea (OR=22, P<0.001). The number of gastrointestinal symptoms was also predictive of hypersensitivity reaction (P<0.001). Respiratory symptoms (cough, sore throat, or dyspnoea) were not associated with abacavir hypersensitivity (OR=0.08, P=0.001). Multivariate analysis confirmed the following associations for abacavir hypersensitivity: the number of gastrointestinal symptoms (OR=8.6, P=0.0032), cough (OR=0.039, P=0.02) and rash (OR=16.9, P=0.07). Abacavir hypersensitivity is strongly associated with gastrointestinal (GI) symptoms. Cough without GI symptoms is associated with influenza.
Original language | English (US) |
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Pages (from-to) | 478-481 |
Number of pages | 4 |
Journal | International Journal of STD and AIDS |
Volume | 14 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2003 |
Externally published | Yes |
Keywords
- Allergy
- Antiretroviral therapy
- Hypersensitivity
- Influenza
ASJC Scopus subject areas
- Dermatology
- Public Health, Environmental and Occupational Health
- Pharmacology (medical)
- Infectious Diseases