Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release

Lawrence D. Snell, Yi Su-Jin Yi, Kenneth M. Johnson

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

MK-801 was found to be more potent than phencyclidine (PCP) as an inhibitor of N-methyl-D-aspartate-induced [3H]norepinephrine (NE) release and [3H]TCP binding in the hippocampus. On the other hand, MK-801 was slightly less potent than PCP to enhance kainate-stimulated [3H]NE release and to inhibit hippocampal [3H]NE uptake. Further, MK-801 was strikingly less potent than PCP as an inhibitor of striatal synaptosomal [3H]dopamine uptake. These data are discussed with reference to the therapeutic potential of MK-801.

Original languageEnglish (US)
Pages (from-to)223-226
Number of pages4
JournalEuropean Journal of Pharmacology
Volume145
Issue number2
DOIs
StatePublished - Jan 12 1988

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Phencyclidine
Dizocilpine Maleate
N-Methylaspartate
Catecholamines
Norepinephrine
Corpus Striatum
Kainic Acid
Hippocampus
Dopamine
Therapeutics

Keywords

  • Dopamine uptake
  • MK-801
  • N-Methyl-D-aspartate-induced release
  • Phencyclidine
  • [H]TCP

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release. / Snell, Lawrence D.; Su-Jin Yi, Yi; Johnson, Kenneth M.

In: European Journal of Pharmacology, Vol. 145, No. 2, 12.01.1988, p. 223-226.

Research output: Contribution to journalArticle

Snell, Lawrence D. ; Su-Jin Yi, Yi ; Johnson, Kenneth M. / Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release. In: European Journal of Pharmacology. 1988 ; Vol. 145, No. 2. pp. 223-226.
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