Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release

Lawrence D. Snell, Yi Su-Jin Yi, Kenneth M. Johnson

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

MK-801 was found to be more potent than phencyclidine (PCP) as an inhibitor of N-methyl-D-aspartate-induced [3H]norepinephrine (NE) release and [3H]TCP binding in the hippocampus. On the other hand, MK-801 was slightly less potent than PCP to enhance kainate-stimulated [3H]NE release and to inhibit hippocampal [3H]NE uptake. Further, MK-801 was strikingly less potent than PCP as an inhibitor of striatal synaptosomal [3H]dopamine uptake. These data are discussed with reference to the therapeutic potential of MK-801.

Original languageEnglish (US)
Pages (from-to)223-226
Number of pages4
JournalEuropean Journal of Pharmacology
Volume145
Issue number2
DOIs
StatePublished - Jan 12 1988

Keywords

  • Dopamine uptake
  • MK-801
  • N-Methyl-D-aspartate-induced release
  • Phencyclidine
  • [H]TCP

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release'. Together they form a unique fingerprint.

  • Cite this