Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release

Lawrence D. Snell; Yi Su-Jin Yi; Kenneth M. Johnson

doi:10.1016/0014-2999(88)90235-X

Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release

Lawrence D. Snell, Yi Su-Jin Yi, Kenneth M. Johnson

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

MK-801 was found to be more potent than phencyclidine (PCP) as an inhibitor of N-methyl-D-aspartate-induced [³H]norepinephrine (NE) release and [³H]TCP binding in the hippocampus. On the other hand, MK-801 was slightly less potent than PCP to enhance kainate-stimulated [³H]NE release and to inhibit hippocampal [³H]NE uptake. Further, MK-801 was strikingly less potent than PCP as an inhibitor of striatal synaptosomal [³H]dopamine uptake. These data are discussed with reference to the therapeutic potential of MK-801.

Original language	English (US)
Pages (from-to)	223-226
Number of pages	4
Journal	European Journal of Pharmacology
Volume	145
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(88)90235-X
State	Published - Jan 12 1988
Externally published	Yes

Keywords

Dopamine uptake
MK-801
N-Methyl-D-aspartate-induced release
Phencyclidine
[H]TCP

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(88)90235-X

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title = "Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release",

abstract = "MK-801 was found to be more potent than phencyclidine (PCP) as an inhibitor of N-methyl-D-aspartate-induced [3H]norepinephrine (NE) release and [3H]TCP binding in the hippocampus. On the other hand, MK-801 was slightly less potent than PCP to enhance kainate-stimulated [3H]NE release and to inhibit hippocampal [3H]NE uptake. Further, MK-801 was strikingly less potent than PCP as an inhibitor of striatal synaptosomal [3H]dopamine uptake. These data are discussed with reference to the therapeutic potential of MK-801.",

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AU - Snell, Lawrence D.

AU - Su-Jin Yi, Yi

AU - Johnson, Kenneth M.

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N2 - MK-801 was found to be more potent than phencyclidine (PCP) as an inhibitor of N-methyl-D-aspartate-induced [3H]norepinephrine (NE) release and [3H]TCP binding in the hippocampus. On the other hand, MK-801 was slightly less potent than PCP to enhance kainate-stimulated [3H]NE release and to inhibit hippocampal [3H]NE uptake. Further, MK-801 was strikingly less potent than PCP as an inhibitor of striatal synaptosomal [3H]dopamine uptake. These data are discussed with reference to the therapeutic potential of MK-801.

AB - MK-801 was found to be more potent than phencyclidine (PCP) as an inhibitor of N-methyl-D-aspartate-induced [3H]norepinephrine (NE) release and [3H]TCP binding in the hippocampus. On the other hand, MK-801 was slightly less potent than PCP to enhance kainate-stimulated [3H]NE release and to inhibit hippocampal [3H]NE uptake. Further, MK-801 was strikingly less potent than PCP as an inhibitor of striatal synaptosomal [3H]dopamine uptake. These data are discussed with reference to the therapeutic potential of MK-801.

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Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release

Abstract

Keywords

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