Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release

Lawrence D. Snell; Yi Su-Jin Yi; Kenneth M. Johnson

doi:10.1016/0014-2999(88)90235-X

Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release

Lawrence D. Snell
, Yi Su-Jin Yi
, Kenneth M. Johnson

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

MK-801 was found to be more potent than phencyclidine (PCP) as an inhibitor of N-methyl-D-aspartate-induced [³H]norepinephrine (NE) release and [³H]TCP binding in the hippocampus. On the other hand, MK-801 was slightly less potent than PCP to enhance kainate-stimulated [³H]NE release and to inhibit hippocampal [³H]NE uptake. Further, MK-801 was strikingly less potent than PCP as an inhibitor of striatal synaptosomal [³H]dopamine uptake. These data are discussed with reference to the therapeutic potential of MK-801.

Original language	English (US)
Pages (from-to)	223-226
Number of pages	4
Journal	European Journal of Pharmacology
Volume	145
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(88)90235-X
State	Published - Jan 12 1988
Externally published	Yes

Keywords

Dopamine uptake
MK-801
N-Methyl-D-aspartate-induced release
Phencyclidine
[H]TCP

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(88)90235-X

Cite this

@article{98f8d61158b14b19b3489c197a900a1a,

title = "Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release",

abstract = "MK-801 was found to be more potent than phencyclidine (PCP) as an inhibitor of N-methyl-D-aspartate-induced [3H]norepinephrine (NE) release and [3H]TCP binding in the hippocampus. On the other hand, MK-801 was slightly less potent than PCP to enhance kainate-stimulated [3H]NE release and to inhibit hippocampal [3H]NE uptake. Further, MK-801 was strikingly less potent than PCP as an inhibitor of striatal synaptosomal [3H]dopamine uptake. These data are discussed with reference to the therapeutic potential of MK-801.",

keywords = "Dopamine uptake, MK-801, N-Methyl-D-aspartate-induced release, Phencyclidine, [H]TCP",

author = "Snell, \{Lawrence D.\} and \{Su-Jin Yi\}, Yi and Johnson, \{Kenneth M.\}",

year = "1988",

month = jan,

day = "12",

doi = "10.1016/0014-2999(88)90235-X",

language = "English (US)",

volume = "145",

pages = "223--226",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release

AU - Snell, Lawrence D.

AU - Su-Jin Yi, Yi

AU - Johnson, Kenneth M.

PY - 1988/1/12

Y1 - 1988/1/12

N2 - MK-801 was found to be more potent than phencyclidine (PCP) as an inhibitor of N-methyl-D-aspartate-induced [3H]norepinephrine (NE) release and [3H]TCP binding in the hippocampus. On the other hand, MK-801 was slightly less potent than PCP to enhance kainate-stimulated [3H]NE release and to inhibit hippocampal [3H]NE uptake. Further, MK-801 was strikingly less potent than PCP as an inhibitor of striatal synaptosomal [3H]dopamine uptake. These data are discussed with reference to the therapeutic potential of MK-801.

AB - MK-801 was found to be more potent than phencyclidine (PCP) as an inhibitor of N-methyl-D-aspartate-induced [3H]norepinephrine (NE) release and [3H]TCP binding in the hippocampus. On the other hand, MK-801 was slightly less potent than PCP to enhance kainate-stimulated [3H]NE release and to inhibit hippocampal [3H]NE uptake. Further, MK-801 was strikingly less potent than PCP as an inhibitor of striatal synaptosomal [3H]dopamine uptake. These data are discussed with reference to the therapeutic potential of MK-801.

KW - Dopamine uptake

KW - MK-801

KW - N-Methyl-D-aspartate-induced release

KW - Phencyclidine

KW - [H]TCP

UR - https://www.scopus.com/pages/publications/0023858504

UR - https://www.scopus.com/pages/publications/0023858504#tab=citedBy

U2 - 10.1016/0014-2999(88)90235-X

DO - 10.1016/0014-2999(88)90235-X

M3 - Article

C2 - 3280329

AN - SCOPUS:0023858504

SN - 0014-2999

VL - 145

SP - 223

EP - 226

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2

ER -

Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this