Comparison of the male osteoporosis risk estimation score (MORES) with frax in identifying men at risk for osteoporosis

Alvah R. Cass, Angela Shepherd, Rechelle Asirot, Manju Mahajan, Maimoona Nizami

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

PURPOSE We wanted to compare the male osteoporosis risk estimation score (MORES) with the fracture risk assessment tool (FRAX) in screening men for osteoporosis. METHODS This study reports analysis of data from the Third National Health and Nutrition Examination Survey (NHANES III), a nationally representative sample of the US population, comparing the operating characteristics of FRAX and MORES to identify men at risk for osteoporosis using a subset of 1,498 men, aged 50 years and older, with a valid dual-energy x-ray absorptiometry (DXA) scan. DXA-derived bone mineral density using a T score of –2.5 or lower at either the femoral neck or total hip defined the diagnosis of osteoporosis. Outcomes included the operating characteristics, area under the receiver-operator characteristic curve, and agreement of the FRAX and MORES. RESULTS Sixty-seven (4.5%) of the 1,498 men had osteoporosis of the hip. The sensitivity, specificity, and area under the curve (AUC) for the MORES were 0.96 (95% CI, 0.87-0.99), 0.61 (95% CI, 0.58-0.63), and 0.87 (95% CI, 0.84-0.91), respectively. The sensitivity, specificity, and AUC for the FRAX were 0.39 (95% CI, 0.27-0.51), 0.89 (95% CI, 0.88-0.91), and 0.79 (95% CI, 0.75-0.84) respectively. Agreement was poor. CONCLUSIONS Compared with the MORES, the FRAX underperformed as a screening strategy for osteoporosis using the threshold score suggested by the US Preventive Services Task Force (USPSTF). An integrated approach that uses the MORES to determine which men should have a DXA scan and the FRAX to guide treatment decisions, based on the risk of a future fracture, identified 82% of men who were candidates for treatments based on National Osteoporosis Foundation guidelines.

Original languageEnglish (US)
Pages (from-to)365-369
Number of pages5
JournalAnnals of Family Medicine
Volume14
Issue number4
DOIs
StatePublished - Jul 1 2016

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Osteoporosis
Nutrition Surveys
X-Rays
Area Under Curve
Hip
Sensitivity and Specificity
Femur Neck
Advisory Committees
Bone Density
Guidelines

Keywords

  • Mass screening
  • Osteoporosis
  • Sensitivity and specificity

ASJC Scopus subject areas

  • Family Practice

Cite this

Comparison of the male osteoporosis risk estimation score (MORES) with frax in identifying men at risk for osteoporosis. / Cass, Alvah R.; Shepherd, Angela; Asirot, Rechelle; Mahajan, Manju; Nizami, Maimoona.

In: Annals of Family Medicine, Vol. 14, No. 4, 01.07.2016, p. 365-369.

Research output: Contribution to journalArticle

Cass, Alvah R. ; Shepherd, Angela ; Asirot, Rechelle ; Mahajan, Manju ; Nizami, Maimoona. / Comparison of the male osteoporosis risk estimation score (MORES) with frax in identifying men at risk for osteoporosis. In: Annals of Family Medicine. 2016 ; Vol. 14, No. 4. pp. 365-369.
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abstract = "PURPOSE We wanted to compare the male osteoporosis risk estimation score (MORES) with the fracture risk assessment tool (FRAX) in screening men for osteoporosis. METHODS This study reports analysis of data from the Third National Health and Nutrition Examination Survey (NHANES III), a nationally representative sample of the US population, comparing the operating characteristics of FRAX and MORES to identify men at risk for osteoporosis using a subset of 1,498 men, aged 50 years and older, with a valid dual-energy x-ray absorptiometry (DXA) scan. DXA-derived bone mineral density using a T score of –2.5 or lower at either the femoral neck or total hip defined the diagnosis of osteoporosis. Outcomes included the operating characteristics, area under the receiver-operator characteristic curve, and agreement of the FRAX and MORES. RESULTS Sixty-seven (4.5{\%}) of the 1,498 men had osteoporosis of the hip. The sensitivity, specificity, and area under the curve (AUC) for the MORES were 0.96 (95{\%} CI, 0.87-0.99), 0.61 (95{\%} CI, 0.58-0.63), and 0.87 (95{\%} CI, 0.84-0.91), respectively. The sensitivity, specificity, and AUC for the FRAX were 0.39 (95{\%} CI, 0.27-0.51), 0.89 (95{\%} CI, 0.88-0.91), and 0.79 (95{\%} CI, 0.75-0.84) respectively. Agreement was poor. CONCLUSIONS Compared with the MORES, the FRAX underperformed as a screening strategy for osteoporosis using the threshold score suggested by the US Preventive Services Task Force (USPSTF). An integrated approach that uses the MORES to determine which men should have a DXA scan and the FRAX to guide treatment decisions, based on the risk of a future fracture, identified 82{\%} of men who were candidates for treatments based on National Osteoporosis Foundation guidelines.",
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AU - Nizami, Maimoona

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N2 - PURPOSE We wanted to compare the male osteoporosis risk estimation score (MORES) with the fracture risk assessment tool (FRAX) in screening men for osteoporosis. METHODS This study reports analysis of data from the Third National Health and Nutrition Examination Survey (NHANES III), a nationally representative sample of the US population, comparing the operating characteristics of FRAX and MORES to identify men at risk for osteoporosis using a subset of 1,498 men, aged 50 years and older, with a valid dual-energy x-ray absorptiometry (DXA) scan. DXA-derived bone mineral density using a T score of –2.5 or lower at either the femoral neck or total hip defined the diagnosis of osteoporosis. Outcomes included the operating characteristics, area under the receiver-operator characteristic curve, and agreement of the FRAX and MORES. RESULTS Sixty-seven (4.5%) of the 1,498 men had osteoporosis of the hip. The sensitivity, specificity, and area under the curve (AUC) for the MORES were 0.96 (95% CI, 0.87-0.99), 0.61 (95% CI, 0.58-0.63), and 0.87 (95% CI, 0.84-0.91), respectively. The sensitivity, specificity, and AUC for the FRAX were 0.39 (95% CI, 0.27-0.51), 0.89 (95% CI, 0.88-0.91), and 0.79 (95% CI, 0.75-0.84) respectively. Agreement was poor. CONCLUSIONS Compared with the MORES, the FRAX underperformed as a screening strategy for osteoporosis using the threshold score suggested by the US Preventive Services Task Force (USPSTF). An integrated approach that uses the MORES to determine which men should have a DXA scan and the FRAX to guide treatment decisions, based on the risk of a future fracture, identified 82% of men who were candidates for treatments based on National Osteoporosis Foundation guidelines.

AB - PURPOSE We wanted to compare the male osteoporosis risk estimation score (MORES) with the fracture risk assessment tool (FRAX) in screening men for osteoporosis. METHODS This study reports analysis of data from the Third National Health and Nutrition Examination Survey (NHANES III), a nationally representative sample of the US population, comparing the operating characteristics of FRAX and MORES to identify men at risk for osteoporosis using a subset of 1,498 men, aged 50 years and older, with a valid dual-energy x-ray absorptiometry (DXA) scan. DXA-derived bone mineral density using a T score of –2.5 or lower at either the femoral neck or total hip defined the diagnosis of osteoporosis. Outcomes included the operating characteristics, area under the receiver-operator characteristic curve, and agreement of the FRAX and MORES. RESULTS Sixty-seven (4.5%) of the 1,498 men had osteoporosis of the hip. The sensitivity, specificity, and area under the curve (AUC) for the MORES were 0.96 (95% CI, 0.87-0.99), 0.61 (95% CI, 0.58-0.63), and 0.87 (95% CI, 0.84-0.91), respectively. The sensitivity, specificity, and AUC for the FRAX were 0.39 (95% CI, 0.27-0.51), 0.89 (95% CI, 0.88-0.91), and 0.79 (95% CI, 0.75-0.84) respectively. Agreement was poor. CONCLUSIONS Compared with the MORES, the FRAX underperformed as a screening strategy for osteoporosis using the threshold score suggested by the US Preventive Services Task Force (USPSTF). An integrated approach that uses the MORES to determine which men should have a DXA scan and the FRAX to guide treatment decisions, based on the risk of a future fracture, identified 82% of men who were candidates for treatments based on National Osteoporosis Foundation guidelines.

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