Comparison of the nucleotide and deduced amino acid sequences of the structural protein genes of the yellow fever 17DD vaccine strain from Senegal with those of other yellow fever vaccine viruses

A. D. Jennings, J. E. Whitby, P. D. Minor, Alan Barrett

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The nucleic acid and deduced amino acid sequences of the structural proteins of the 17DD vaccine strain of yellow fever (YF) virus originating from Senegal are compared with those published for other vaccine strains of YF virus. Even though the 17D-204 and 17DD substrains of 17D diverged at passage 195 of 17D, they show a very high degree of nucleotide (99.5%) and amino acid (99.5%) homology over this region. The sequences are discussed with respect to monoclonal antibodies that can distinguish between 17DD and 17D-204 substrains of YF vaccines.

Original languageEnglish (US)
Pages (from-to)679-681
Number of pages3
JournalVaccine
Volume11
Issue number6
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Yellow Fever Vaccine
Yellow fever virus
Senegal
structural proteins
Amino Acid Sequence
Vaccines
amino acid sequences
Nucleotides
nucleotides
vaccines
viruses
Nucleic Acids
Proteins
genes
Monoclonal Antibodies
Amino Acids
nucleic acids
monoclonal antibodies
amino acids

Keywords

  • flavivirus
  • structural proteins
  • Yellow fever

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

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abstract = "The nucleic acid and deduced amino acid sequences of the structural proteins of the 17DD vaccine strain of yellow fever (YF) virus originating from Senegal are compared with those published for other vaccine strains of YF virus. Even though the 17D-204 and 17DD substrains of 17D diverged at passage 195 of 17D, they show a very high degree of nucleotide (99.5{\%}) and amino acid (99.5{\%}) homology over this region. The sequences are discussed with respect to monoclonal antibodies that can distinguish between 17DD and 17D-204 substrains of YF vaccines.",
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T1 - Comparison of the nucleotide and deduced amino acid sequences of the structural protein genes of the yellow fever 17DD vaccine strain from Senegal with those of other yellow fever vaccine viruses

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AU - Whitby, J. E.

AU - Minor, P. D.

AU - Barrett, Alan

PY - 1993

Y1 - 1993

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AB - The nucleic acid and deduced amino acid sequences of the structural proteins of the 17DD vaccine strain of yellow fever (YF) virus originating from Senegal are compared with those published for other vaccine strains of YF virus. Even though the 17D-204 and 17DD substrains of 17D diverged at passage 195 of 17D, they show a very high degree of nucleotide (99.5%) and amino acid (99.5%) homology over this region. The sequences are discussed with respect to monoclonal antibodies that can distinguish between 17DD and 17D-204 substrains of YF vaccines.

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