Comparison of the Nucleotide and Deduced Amino Acid Sequences of the Envelope Protein Genes of the Wild-Type French Viscerotropic Strain of Yellow Fever Virus and the Live Vaccine Strain, French Neurotropic Vaccine, Derived from It

A. D. Jennings, J. E. Whitby, P. D. Minor, Alan Barrett

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The envelope (E) protein genes of the wild-type yellow fever (YF) virus French viscerotropic virus and its' vaccine derivative, French neurotropic virus (FNV), were compared and found to differ by 13 nucleotides that coded for 8 amino acid substitutions. Comparison of the E proteins of FNV and 17D, the vaccine strain derived from wild-type strain Asibi, showed that there was no common nucleotide change or amino acid substitution between these two vaccine strains. However, changes are clustered around amino acid positions 52-56 and may represent the common vaccine epitope shared by 17D and FNV vaccine viruses. The molecular basis of any difference in neurotropism and viscerotropism of YF virus, attributable to the E protein, remains unclear.

Original languageEnglish (US)
Pages (from-to)692-695
Number of pages4
JournalVirology
Volume192
Issue number2
DOIs
StatePublished - Feb 1993
Externally publishedYes

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Yellow fever virus
Amino Acid Sequence
Vaccines
Nucleotides
Viruses
Amino Acid Substitution
Proteins
Epitopes
Amino Acids

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

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abstract = "The envelope (E) protein genes of the wild-type yellow fever (YF) virus French viscerotropic virus and its' vaccine derivative, French neurotropic virus (FNV), were compared and found to differ by 13 nucleotides that coded for 8 amino acid substitutions. Comparison of the E proteins of FNV and 17D, the vaccine strain derived from wild-type strain Asibi, showed that there was no common nucleotide change or amino acid substitution between these two vaccine strains. However, changes are clustered around amino acid positions 52-56 and may represent the common vaccine epitope shared by 17D and FNV vaccine viruses. The molecular basis of any difference in neurotropism and viscerotropism of YF virus, attributable to the E protein, remains unclear.",
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