Comparison of the potency of antihistamines

Sharlene Llanes, J. Andrew Grant

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

First- and second-generation antihistamines have proven effective in the management of patients with urticaria and allergic rhinitis; however, the efficacy of first-generation antihistamines has been compromised by undesirable side effects such as sedation, dry mouth, and blurred vision. Second-generation antihistamines, on the other hand, are less sedating and have fewer side effects than first-generation agents. Recently second-generation agents have been compared for their pharmacologic activities using an epicutaneous histamine-induced wheal and flare model in normal volunteers. Cetirizine was found to be superior to epinastine, ebastine, fexofenadine, terfenadine, loratadine, and placebo in inhibiting the wheal and flare response. Epinastine had the fastest onset of action at 30 minutes and terfenadine proved to be superior to its metabolite fexofenadine.

Original languageEnglish (US)
Pages (from-to)344-348
Number of pages5
JournalDermatologic Therapy
Volume13
Issue number4
DOIs
StatePublished - 2000

Fingerprint

fexofenadine
Non-Sedating Histamine H1 Antagonists
Terfenadine
Histamine Antagonists
Loratadine
Cetirizine
Cohort Effect
Urticaria
Histamine
Mouth
Healthy Volunteers
Placebos
epinastine

Keywords

  • Cetirizine
  • Ebastine
  • Epinastine
  • Fexofenadine
  • Loratadine
  • Terfenadine

ASJC Scopus subject areas

  • Dermatology

Cite this

Comparison of the potency of antihistamines. / Llanes, Sharlene; Andrew Grant, J.

In: Dermatologic Therapy, Vol. 13, No. 4, 2000, p. 344-348.

Research output: Contribution to journalArticle

Llanes, Sharlene ; Andrew Grant, J. / Comparison of the potency of antihistamines. In: Dermatologic Therapy. 2000 ; Vol. 13, No. 4. pp. 344-348.
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