Compensatory glomerular growth after unilateral nephrectomy is VEGF dependent

Allan Flyvbjerg, Bieke F. Schrijvers, A. N S De Vriese, Ronald Tilton, Ruth Rasch

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Various growth factors and cytokines have been implicated in different forms of kidney enlargement. Vascular endothelial growth factor (VEGF) is essential for normal renal development and plays a role in diabetic glomerular enlargement. To explore a possible role for VEGF in compensatory renal changes after uninephrectomy, we examined the effect of a neutralizing VEGF-antibody (VEGF-Ab) on glomerular volume and kidney weight in mice treated for 7 days. Serum and kidney insulin-like growth factor I (IGF-I) levels were measured, since IGF-I has been implicated in the pathogenesis of compensatory renal growth, and VEGF has been suggested to be a downstream mediator of IGF-I. Placebo-treated uninephrectomized mice displayed an early transient increase in kidney IGF-I concentration and an increase in glomerular volume and kidney weight. In VEGF-Ab-treated uninephrectomized animals, increased glomerular volume was abolished, whereas renal hypertrophy was partially blocked. Furthermore, the renal effects of VEGF-Ab administration were seen without affecting the renal IGF-I levels. In conclusion, these results demonstrate that compensatory glomerular growth after uninephrectomy is VEGF dependent.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume283
Issue number2 46-2
StatePublished - 2002
Externally publishedYes

Fingerprint

Nephrectomy
Vascular Endothelial Growth Factor A
Insulin-Like Growth Factor I
Kidney
Growth
Intercellular Signaling Peptides and Proteins
Weights and Measures
Animals
Cytokines
Hypertrophy
Antibodies
Placebos

Keywords

  • Compensatory renal growth
  • Glomerular volume
  • Insulin-like growth factor I
  • Kidney weight
  • Vascular endothelial growth factor-antibody

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry

Cite this

Flyvbjerg, A., Schrijvers, B. F., De Vriese, A. N. S., Tilton, R., & Rasch, R. (2002). Compensatory glomerular growth after unilateral nephrectomy is VEGF dependent. American Journal of Physiology - Endocrinology and Metabolism, 283(2 46-2).

Compensatory glomerular growth after unilateral nephrectomy is VEGF dependent. / Flyvbjerg, Allan; Schrijvers, Bieke F.; De Vriese, A. N S; Tilton, Ronald; Rasch, Ruth.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 283, No. 2 46-2, 2002.

Research output: Contribution to journalArticle

Flyvbjerg, A, Schrijvers, BF, De Vriese, ANS, Tilton, R & Rasch, R 2002, 'Compensatory glomerular growth after unilateral nephrectomy is VEGF dependent', American Journal of Physiology - Endocrinology and Metabolism, vol. 283, no. 2 46-2.
Flyvbjerg, Allan ; Schrijvers, Bieke F. ; De Vriese, A. N S ; Tilton, Ronald ; Rasch, Ruth. / Compensatory glomerular growth after unilateral nephrectomy is VEGF dependent. In: American Journal of Physiology - Endocrinology and Metabolism. 2002 ; Vol. 283, No. 2 46-2.
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