Compensatory renal growth: Interactions of nephrectomy serum and urine antisera leading to a new theory of renal growth regulation

B. W. Snow, W. F. Tarry, J. W. Duckett

    Research output: Contribution to journalArticle

    4 Scopus citations

    Abstract

    Compensatory renal growth is mediated by a substance(s) found in the serum and in urine called renotropin. The interaction of nephrectomy serum and urine antisera upon compensatory renal growth was investigated by administering rat uninephrectomy serum and sham serum and urine to rabbits. The rabbit antisera was given intravenously to uninephrectomy and sham operated rats and kidney weight/body weight ratios were calculated. Antisera against sham serum and urine induced kidney growth as well as antisera aginst uninephrectomy serum and urine given to sham animals. These results suggest the presence of a circulating antigenic inhibitor to kidney growth and suggest that renotropin is made up of a inhibitory as well as a stimulatory substance.

    Original languageEnglish (US)
    Pages (from-to)1-4
    Number of pages4
    JournalUrological Research
    Volume15
    Issue number1
    DOIs
    StatePublished - Feb 1 1987

    Keywords

    • Compensatory renal growth
    • Kidney growth regulation
    • Obligatory renal growth
    • Renotropin

    ASJC Scopus subject areas

    • Urology

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