Compensatory renal growth: Interactions of nephrectomy serum and urine antisera leading to a new theory of renal growth regulation

B. W. Snow, W. F. Tarry, J. W. Duckett

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Compensatory renal growth is mediated by a substance(s) found in the serum and in urine called renotropin. The interaction of nephrectomy serum and urine antisera upon compensatory renal growth was investigated by administering rat uninephrectomy serum and sham serum and urine to rabbits. The rabbit antisera was given intravenously to uninephrectomy and sham operated rats and kidney weight/body weight ratios were calculated. Antisera against sham serum and urine induced kidney growth as well as antisera aginst uninephrectomy serum and urine given to sham animals. These results suggest the presence of a circulating antigenic inhibitor to kidney growth and suggest that renotropin is made up of a inhibitory as well as a stimulatory substance.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalUrological Research
Volume15
Issue number1
DOIs
StatePublished - Feb 1987
Externally publishedYes

Keywords

  • Compensatory renal growth
  • Kidney growth regulation
  • Obligatory renal growth
  • Renotropin

ASJC Scopus subject areas

  • Urology

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