Complete nucleotide sequences of Marburg virus genes 5 and 6 encoding VP30 and VP24 proteins

A. A. Bukreyev, E. F. Belanov, V. M. Blinov, S. V. Netesov

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Nucleotide sequences of the genes 5 and 6 of the Marburg virus, Popp strain, were determined. ORFs encoding polypeptides VP30 (281 a.a., MW 32,640) and VP24 (253 a.a., MW 28,621) were found. The putative transcription start and stop signals for viral RNA-dependent RNA polymerase were revealed for both genes. Overlapping of genes 5 and 6 was shown. The deduced amino acid sequences of VP30 and VP24 proteins displayed significant homology with the analogous proteins of another filovirus, the Ebola virus (33% and 37%, respectively). The VP24 appeared to have a hydrophobic amino acid composition; content of hydrophobic amino acids was 40,7%. Model of VP24 location in the virion was suggested.

Original languageEnglish (US)
Pages (from-to)605-613
Number of pages9
JournalBiochemistry and Molecular Biology International
Volume35
Issue number3
StatePublished - Dec 1 1995

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Complete nucleotide sequences of Marburg virus genes 5 and 6 encoding VP30 and VP24 proteins'. Together they form a unique fingerprint.

  • Cite this