@article{edf12888799845f0aadbc0d3eb44dfea,
title = "Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross",
abstract = "Noll et al. use the Collaborative Cross, a mouse genetic reference population, to map genetic loci associated with variation in the humoral response to influenza virus infection. Cross-dataset comparison shows that mapped loci are important for antibody response to multiple pathogens, and candidate genes with likely translational relevance are identified.",
keywords = "Collaborative Cross, antibody, complex trait, genetic architecture, genetic mapping, genetic reference population, host genetics, humoral immunity, influenza, influenza virus",
author = "Noll, {Kelsey E.} and Whitmore, {Alan C.} and Ande West and McCarthy, {Mary K.} and Morrison, {Clayton R.} and Plante, {Kenneth S.} and Hampton, {Brea K.} and Heike Kollmus and Carolin Pilzner and Leist, {Sarah R.} and Gralinski, {Lisa E.} and Menachery, {Vineet D.} and Alexandra Sch{\"a}fer and Darla Miller and Ginger Shaw and Michael Mooney and Shannon McWeeney and {Pardo-Manuel de Villena}, Fernando and Klaus Schughart and Morrison, {Thomas E.} and Baric, {Ralph S.} and Ferris, {Martin T.} and Heise, {Mark T.}",
note = "Funding Information: We would like to acknowledge the Systems Genetics Core Facility at UNC for their maintenance and distribution of CC mouse strains as well as their pertinent genetic information. We thank the animal caretakers at the Central Animal Facilities of the HZI for maintaining the mice; Stefanie Edler, Karin Lammert, Christin Kurch, and Rebecka W{\"u}nsche for technical assistance; and Michael Jarek, Richard Green, Frank Fernandez, Till Lesker, and Robert Geffers (HZI) for support with the analysis of RNA sequencing (RNA-seq) data. RNA-seq has been performed by the Molecular Resource Center (MRC) at UTHSC, Memphis. This work was supported by NIH / NIAID research grants U19-AI100625 , U01 AI149644 , and U19 AI 109761 to R.S.B. and M.T.H.; U19 AI 109680 and R21 AI119933 to M.T.H.; R01 AI141416 to T.E.M.; intra-mural grants from the Helmholtz-Association (Program Infection and Immunity); a start-up grant from the University of Tennessee Health Science Center ; and the research grant FluResearchNet ( 01KI1006F ) from the German Ministry of Education and Research to K.S. K.E.N. was supported by NIH / NIAID grant T32 AI007419 , K.S.P. was supported by NIH / NIAID grants T32 AI007151-36A1 and F32 AI126730 , and M.K.M. was supported by NIH / NIAID grant F32 AI122436 . Funding Information: We would like to acknowledge the Systems Genetics Core Facility at UNC for their maintenance and distribution of CC mouse strains as well as their pertinent genetic information. We thank the animal caretakers at the Central Animal Facilities of the HZI for maintaining the mice; Stefanie Edler, Karin Lammert, Christin Kurch, and Rebecka W{\"u}nsche for technical assistance; and Michael Jarek, Richard Green, Frank Fernandez, Till Lesker, and Robert Geffers (HZI) for support with the analysis of RNA sequencing (RNA-seq) data. RNA-seq has been performed by the Molecular Resource Center (MRC) at UTHSC, Memphis. This work was supported by NIH/NIAID research grants U19-AI100625, U01 AI149644, and U19 AI 109761 to R.S.B. and M.T.H.; U19 AI 109680 and R21 AI119933 to M.T.H.; R01 AI141416 to T.E.M.; intra-mural grants from the Helmholtz-Association (Program Infection and Immunity); a start-up grant from the University of Tennessee Health Science Center; and the research grant FluResearchNet (01KI1006F) from the German Ministry of Education and Research to K.S. K.E.N. was supported by NIH/NIAID grant T32 AI007419, K.S.P. was supported by NIH/NIAID grants T32 AI007151-36A1 and F32 AI126730, and M.K.M. was supported by NIH/NIAID grant F32 AI122436. These studies were designed by K.E.N. A.C.W. L.E.G. V.D.M. S.M. F.P.-M.d.V. K.S. T.E.M. R.S.B. M.T.F. and M.T.H. These experiments were conducted by K.E.N. A.C.W. A.W. M.K.M. C.R.M. K.S.P. B.K.H. H.K. C.P. S.R.L. L.E.G. V.D.M. A.S. D.M. G.S. and M.T.F. The data were analyzed by K.E.N. H.K. M.M. S.M. K.S. M.T.F. and M.T.H. The manuscript was written primarily by K.E.N. M.T.F. and M.T.H. All authors contributed to the editing of this manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = apr,
day = "28",
doi = "10.1016/j.celrep.2020.107587",
language = "English (US)",
volume = "31",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "4",
}