Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross

Kelsey E. Noll; Alan C. Whitmore; Ande West; Mary K. McCarthy; Clayton R. Morrison; Kenneth S. Plante; Brea K. Hampton; Heike Kollmus; Carolin Pilzner; Sarah R. Leist; Lisa E. Gralinski; Vineet D. Menachery; Alexandra Schäfer; Darla Miller; Ginger Shaw; Michael Mooney; Shannon McWeeney; Fernando Pardo-Manuel de Villena; Klaus Schughart; Thomas E. Morrison; Ralph S. Baric; Martin T. Ferris; Mark T. Heise

doi:10.1016/j.celrep.2020.107587

Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross

Kelsey E. Noll
, Alan C. Whitmore
, Ande West
, Mary K. McCarthy
, Clayton R. Morrison
, Kenneth S. Plante
, Brea K. Hampton
, Heike Kollmus
, Carolin Pilzner
, Sarah R. Leist
, Lisa E. Gralinski
, Vineet D. Menachery
, Alexandra Schäfer
, Darla Miller
, Ginger Shaw
, Michael Mooney
, Shannon McWeeney
, Fernando Pardo-Manuel de Villena
, Klaus Schughart
, Thomas E. Morrison

Ralph S. Baric, Martin T. Ferris, Mark T. Heise

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Noll et al. use the Collaborative Cross, a mouse genetic reference population, to map genetic loci associated with variation in the humoral response to influenza virus infection. Cross-dataset comparison shows that mapped loci are important for antibody response to multiple pathogens, and candidate genes with likely translational relevance are identified.

Original language	English (US)
Article number	107587
Journal	Cell Reports
Volume	31
Issue number	4
DOIs	https://doi.org/10.1016/j.celrep.2020.107587
State	Published - Apr 28 2020

Keywords

Collaborative Cross
antibody
complex trait
genetic architecture
genetic mapping
genetic reference population
host genetics
humoral immunity
influenza
influenza virus

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2020.107587

Cite this

Noll, K. E., Whitmore, A. C., West, A., McCarthy, M. K., Morrison, C. R., Plante, K. S., Hampton, B. K., Kollmus, H., Pilzner, C., Leist, S. R., Gralinski, L. E., Menachery, V. D., Schäfer, A., Miller, D., Shaw, G., Mooney, M., McWeeney, S., Pardo-Manuel de Villena, F., Schughart, K., ... Heise, M. T. (2020). Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross. Cell Reports, 31(4), Article 107587. https://doi.org/10.1016/j.celrep.2020.107587

Noll, KE, Whitmore, AC, West, A, McCarthy, MK, Morrison, CR, Plante, KS, Hampton, BK, Kollmus, H, Pilzner, C, Leist, SR, Gralinski, LE, Menachery, VD, Schäfer, A, Miller, D, Shaw, G, Mooney, M, McWeeney, S, Pardo-Manuel de Villena, F, Schughart, K, Morrison, TE, Baric, RS, Ferris, MT & Heise, MT 2020, 'Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross', Cell Reports, vol. 31, no. 4, 107587. https://doi.org/10.1016/j.celrep.2020.107587

@article{edf12888799845f0aadbc0d3eb44dfea,

title = "Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross",

abstract = "Noll et al. use the Collaborative Cross, a mouse genetic reference population, to map genetic loci associated with variation in the humoral response to influenza virus infection. Cross-dataset comparison shows that mapped loci are important for antibody response to multiple pathogens, and candidate genes with likely translational relevance are identified.",

keywords = "Collaborative Cross, antibody, complex trait, genetic architecture, genetic mapping, genetic reference population, host genetics, humoral immunity, influenza, influenza virus",

author = "Noll, \{Kelsey E.\} and Whitmore, \{Alan C.\} and Ande West and McCarthy, \{Mary K.\} and Morrison, \{Clayton R.\} and Plante, \{Kenneth S.\} and Hampton, \{Brea K.\} and Heike Kollmus and Carolin Pilzner and Leist, \{Sarah R.\} and Gralinski, \{Lisa E.\} and Menachery, \{Vineet D.\} and Alexandra Sch{\"a}fer and Darla Miller and Ginger Shaw and Michael Mooney and Shannon McWeeney and \{Pardo-Manuel de Villena\}, Fernando and Klaus Schughart and Morrison, \{Thomas E.\} and Baric, \{Ralph S.\} and Ferris, \{Martin T.\} and Heise, \{Mark T.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = apr,

day = "28",

doi = "10.1016/j.celrep.2020.107587",

language = "English (US)",

volume = "31",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier BV",

number = "4",

}

TY - JOUR

T1 - Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross

AU - Noll, Kelsey E.

AU - Whitmore, Alan C.

AU - West, Ande

AU - McCarthy, Mary K.

AU - Morrison, Clayton R.

AU - Plante, Kenneth S.

AU - Hampton, Brea K.

AU - Kollmus, Heike

AU - Pilzner, Carolin

AU - Leist, Sarah R.

AU - Gralinski, Lisa E.

AU - Menachery, Vineet D.

AU - Schäfer, Alexandra

AU - Miller, Darla

AU - Shaw, Ginger

AU - Mooney, Michael

AU - McWeeney, Shannon

AU - Pardo-Manuel de Villena, Fernando

AU - Schughart, Klaus

AU - Morrison, Thomas E.

AU - Baric, Ralph S.

AU - Ferris, Martin T.

AU - Heise, Mark T.

PY - 2020/4/28

Y1 - 2020/4/28

N2 - Noll et al. use the Collaborative Cross, a mouse genetic reference population, to map genetic loci associated with variation in the humoral response to influenza virus infection. Cross-dataset comparison shows that mapped loci are important for antibody response to multiple pathogens, and candidate genes with likely translational relevance are identified.

AB - Noll et al. use the Collaborative Cross, a mouse genetic reference population, to map genetic loci associated with variation in the humoral response to influenza virus infection. Cross-dataset comparison shows that mapped loci are important for antibody response to multiple pathogens, and candidate genes with likely translational relevance are identified.

KW - Collaborative Cross

KW - antibody

KW - complex trait

KW - genetic architecture

KW - genetic mapping

KW - genetic reference population

KW - host genetics

KW - humoral immunity

KW - influenza

KW - influenza virus

UR - https://www.scopus.com/pages/publications/85083790557

UR - https://www.scopus.com/pages/publications/85083790557#tab=citedBy

U2 - 10.1016/j.celrep.2020.107587

DO - 10.1016/j.celrep.2020.107587

M3 - Article

C2 - 32348764

AN - SCOPUS:85083790557

SN - 2211-1247

VL - 31

JO - Cell Reports

JF - Cell Reports

IS - 4

M1 - 107587

ER -

Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this