Complex glycan catabolism by the human gut microbiota: The bacteroidetes sus-like paradigm

Eric C. Martens, Nicole M. Koropatkin, Thomas Smith, Jeffrey I. Gordon

Research output: Contribution to journalArticle

296 Citations (Scopus)

Abstract

Trillions of microbes inhabit the distal gut of adult humans. They have evolved to compete efficiently for nutrients, including a wide array of chemically diverse, complex glycans present in our diets, secreted by our intestinal mucosa, and displayed on the surfaces of other gut microbes. Here, we review how members of the Bacteroidetes, one of two dominant gut-associated bacterial phyla, process complex glycans using a series of similarly patterned, cell envelope-associated multiprotein systems. These systems provide insights into how gut, as well as terrestrial and aquatic, Bacteroidetes survive in highly competitive ecosystems.

Original languageEnglish (US)
Pages (from-to)24673-24677
Number of pages5
JournalJournal of Biological Chemistry
Volume284
Issue number37
DOIs
StatePublished - Sep 11 2009
Externally publishedYes

Fingerprint

Bacteroidetes
Polysaccharides
Bacterial Physiological Phenomena
Intestinal Mucosa
Nutrition
Ecosystems
Nutrients
Ecosystem
Diet
Food
Gastrointestinal Microbiome
Mucous Membrane

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Complex glycan catabolism by the human gut microbiota : The bacteroidetes sus-like paradigm. / Martens, Eric C.; Koropatkin, Nicole M.; Smith, Thomas; Gordon, Jeffrey I.

In: Journal of Biological Chemistry, Vol. 284, No. 37, 11.09.2009, p. 24673-24677.

Research output: Contribution to journalArticle

Martens, Eric C. ; Koropatkin, Nicole M. ; Smith, Thomas ; Gordon, Jeffrey I. / Complex glycan catabolism by the human gut microbiota : The bacteroidetes sus-like paradigm. In: Journal of Biological Chemistry. 2009 ; Vol. 284, No. 37. pp. 24673-24677.
@article{526007695d9a4d2ca7a76e084e902e47,
title = "Complex glycan catabolism by the human gut microbiota: The bacteroidetes sus-like paradigm",
abstract = "Trillions of microbes inhabit the distal gut of adult humans. They have evolved to compete efficiently for nutrients, including a wide array of chemically diverse, complex glycans present in our diets, secreted by our intestinal mucosa, and displayed on the surfaces of other gut microbes. Here, we review how members of the Bacteroidetes, one of two dominant gut-associated bacterial phyla, process complex glycans using a series of similarly patterned, cell envelope-associated multiprotein systems. These systems provide insights into how gut, as well as terrestrial and aquatic, Bacteroidetes survive in highly competitive ecosystems.",
author = "Martens, {Eric C.} and Koropatkin, {Nicole M.} and Thomas Smith and Gordon, {Jeffrey I.}",
year = "2009",
month = "9",
day = "11",
doi = "10.1074/jbc.R109.022848",
language = "English (US)",
volume = "284",
pages = "24673--24677",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "37",

}

TY - JOUR

T1 - Complex glycan catabolism by the human gut microbiota

T2 - The bacteroidetes sus-like paradigm

AU - Martens, Eric C.

AU - Koropatkin, Nicole M.

AU - Smith, Thomas

AU - Gordon, Jeffrey I.

PY - 2009/9/11

Y1 - 2009/9/11

N2 - Trillions of microbes inhabit the distal gut of adult humans. They have evolved to compete efficiently for nutrients, including a wide array of chemically diverse, complex glycans present in our diets, secreted by our intestinal mucosa, and displayed on the surfaces of other gut microbes. Here, we review how members of the Bacteroidetes, one of two dominant gut-associated bacterial phyla, process complex glycans using a series of similarly patterned, cell envelope-associated multiprotein systems. These systems provide insights into how gut, as well as terrestrial and aquatic, Bacteroidetes survive in highly competitive ecosystems.

AB - Trillions of microbes inhabit the distal gut of adult humans. They have evolved to compete efficiently for nutrients, including a wide array of chemically diverse, complex glycans present in our diets, secreted by our intestinal mucosa, and displayed on the surfaces of other gut microbes. Here, we review how members of the Bacteroidetes, one of two dominant gut-associated bacterial phyla, process complex glycans using a series of similarly patterned, cell envelope-associated multiprotein systems. These systems provide insights into how gut, as well as terrestrial and aquatic, Bacteroidetes survive in highly competitive ecosystems.

UR - http://www.scopus.com/inward/record.url?scp=69949094849&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69949094849&partnerID=8YFLogxK

U2 - 10.1074/jbc.R109.022848

DO - 10.1074/jbc.R109.022848

M3 - Article

C2 - 19553672

AN - SCOPUS:69949094849

VL - 284

SP - 24673

EP - 24677

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 37

ER -