Complications associated with sentinel lymph node biopsy for melanoma

William R. Wrightson, Sandra L. Wong, Michael J. Edwards, Celia Chao, Douglas S. Reintgen, Merrick I. Ross, R. Dirk Noyes, Vicki Viar, Patricia B. Cerrito, Kelly M. McMasters

Research output: Contribution to journalArticle

213 Citations (Scopus)

Abstract

Background: Sentinel lymph node (SLN) biopsy has become widely accepted as a method of staging the regional lymph nodes for patients with melanoma. Although it is often stated that SLN biopsy is a minimally invasive procedure associated with few complications, a paucity of data exists to specifically determine the morbidity associated with this procedure. This analysis was performed to evaluate the morbidity associated with SLN biopsy compared with completion lymph node dissection (CLND). Methods: Patients were enrolled in the Sunbelt Melanoma Trial, a prospective multi-institutional study of SLN biopsy for melanoma. Patients underwent SLN biopsy and were prospectively followed up for the development of complications associated with this technique. Patients who had evidence of nodal metastasis in the SLN underwent CLND. Complications associated with SLN biopsy alone were compared with those associated with SLN biopsy plus CLND. Results: A total of 2120 patients were evaluated, with a median follow-up of 16 months. Overall, 96 (4.6%) of 2120 patients developed major or minor complications associated with SLN biopsy, whereas 103 (23.2%) of 444 patients experienced complications associated with SLN biopsy plus CLND. There were no deaths associated with either procedure. Conclusions: SLN biopsy alone is associated with significantly less morbidity compared with SLN biopsy plus CLND.

Original languageEnglish (US)
Pages (from-to)676-680
Number of pages5
JournalAnnals of Surgical Oncology
Volume10
Issue number6
DOIs
StatePublished - 2003
Externally publishedYes

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Sentinel Lymph Node Biopsy
Melanoma
Lymph Node Excision
Morbidity
Lymph Nodes

Keywords

  • Complications
  • Lymph node dissection
  • Melanoma
  • Morbidity
  • Sentinel lymph node

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Wrightson, W. R., Wong, S. L., Edwards, M. J., Chao, C., Reintgen, D. S., Ross, M. I., ... McMasters, K. M. (2003). Complications associated with sentinel lymph node biopsy for melanoma. Annals of Surgical Oncology, 10(6), 676-680. https://doi.org/10.1245/ASO.2003.10.001

Complications associated with sentinel lymph node biopsy for melanoma. / Wrightson, William R.; Wong, Sandra L.; Edwards, Michael J.; Chao, Celia; Reintgen, Douglas S.; Ross, Merrick I.; Noyes, R. Dirk; Viar, Vicki; Cerrito, Patricia B.; McMasters, Kelly M.

In: Annals of Surgical Oncology, Vol. 10, No. 6, 2003, p. 676-680.

Research output: Contribution to journalArticle

Wrightson, WR, Wong, SL, Edwards, MJ, Chao, C, Reintgen, DS, Ross, MI, Noyes, RD, Viar, V, Cerrito, PB & McMasters, KM 2003, 'Complications associated with sentinel lymph node biopsy for melanoma', Annals of Surgical Oncology, vol. 10, no. 6, pp. 676-680. https://doi.org/10.1245/ASO.2003.10.001
Wrightson, William R. ; Wong, Sandra L. ; Edwards, Michael J. ; Chao, Celia ; Reintgen, Douglas S. ; Ross, Merrick I. ; Noyes, R. Dirk ; Viar, Vicki ; Cerrito, Patricia B. ; McMasters, Kelly M. / Complications associated with sentinel lymph node biopsy for melanoma. In: Annals of Surgical Oncology. 2003 ; Vol. 10, No. 6. pp. 676-680.
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