Complications of Long-Term Prostaglandin E1 Use in Newborns with Ductal-Dependent Critical Congenital Heart Disease

Walid Alhussin, M. Terese Verklan

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Prostaglandin E1 (PGE1) has been used for decades in the medical treatment of ductal dependent critical congenital heart disease in neonates. The article is a report of a retrospective evaluation of the long-term effects of PGE1 in a neonatal intensive care unit in Saudi Arabia. There were 22 subjects with a wide spectrum of cardiac defects maintained on PGE1 for a mean of 38 days (range: 6-200 days). The majority of the complications included hypokalemia, hypotension, and apnea/bradycardia. Pseudo-Barett syndrome and gastric outlet obstruction were also found. While long-term administration of PGE1 is rare in North America, it is important to be aware of possible adverse effects of fluid and electrolyte imbalance, gastric outlet obstruction, and feeding difficulties.

    Original languageEnglish (US)
    Pages (from-to)73-79
    Number of pages7
    JournalJournal of Perinatal and Neonatal Nursing
    Volume30
    Issue number1
    DOIs
    StatePublished - 2016

    Fingerprint

    Alprostadil
    Heart Diseases
    Gastric Outlet Obstruction
    Hypokalemia
    Saudi Arabia
    Neonatal Intensive Care Units
    Apnea
    Bradycardia
    North America
    Hypotension
    Electrolytes
    Therapeutics

    Keywords

    • congenital heart disease
    • neonate
    • prostaglandin

    ASJC Scopus subject areas

    • Pediatrics
    • Critical Care
    • Maternity and Midwifery

    Cite this

    Complications of Long-Term Prostaglandin E1 Use in Newborns with Ductal-Dependent Critical Congenital Heart Disease. / Alhussin, Walid; Verklan, M. Terese.

    In: Journal of Perinatal and Neonatal Nursing, Vol. 30, No. 1, 2016, p. 73-79.

    Research output: Contribution to journalArticle

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