Comprehensive analysis of genetic polymorphisms in the interleukin-10 promoter

Implications for immune regulation in specific ethnic populations

Peter L. Rady, Reuben Matalon, James Grady, Eric M. Smith, S. David Hudnall, Leonard H. Kellner, Harold Nitowsky, Stephen K. Tyring, Thomas K. Hughes

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The association of interleukin-10 (IL-10) promoter single-nucleotide polymorphisms (SNPS) as risk factors for certain inflammatory diseases, viral infections, cancers, and transplant rejection have been the subject of recent studies. The SNPs-1082 G → A, -819 C → T, and -592 C → A, which have been associated with differential IL-10 production, are strongly linked with ethnicity. In this study, we determined the ethnic distribution of IL-10 promoter SNPs and their haplotype rates among Hispanics, African Americans, and Caucasians from Texas and Ashkenazi Jews from New York. Significant differences in prevalence rates of IL-10 SNPs (and their haplotype distribution) were found. African Americans and Hispanics have a lower rate of putative high-producer SNPs and a higher rate of low IL-10 producers when compared to Caucasians or Ashkenazi Jews. No statistically significant differences in allelic frequencies and haplotype rates were observed between Caucasians and Ashkenazi Jews. This study provides critical new information on the ethnic distribution of IL-10 promoter SNPs in a regional U.S. population and is the first to analyze the rate of SNPs in an unstudied ethnic population, Ashkenazi Jews. Knowledge of IL-10 promoter polymorphisms may prove useful in prediction of immunization responses, disease severity, and in the intelligent design of customized immunotherapy.

Original languageEnglish (US)
Pages (from-to)194-203
Number of pages10
JournalGenetic Testing
Volume8
Issue number2
DOIs
StatePublished - Jun 2004

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Genetic Polymorphisms
Interleukin-10
Single Nucleotide Polymorphism
Jews
Population
Haplotypes
Hispanic Americans
African Americans
Religious Philosophies
Graft Rejection
Virus Diseases
Immunotherapy
Immunization
Neoplasms

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Comprehensive analysis of genetic polymorphisms in the interleukin-10 promoter : Implications for immune regulation in specific ethnic populations. / Rady, Peter L.; Matalon, Reuben; Grady, James; Smith, Eric M.; Hudnall, S. David; Kellner, Leonard H.; Nitowsky, Harold; Tyring, Stephen K.; Hughes, Thomas K.

In: Genetic Testing, Vol. 8, No. 2, 06.2004, p. 194-203.

Research output: Contribution to journalArticle

Rady, Peter L. ; Matalon, Reuben ; Grady, James ; Smith, Eric M. ; Hudnall, S. David ; Kellner, Leonard H. ; Nitowsky, Harold ; Tyring, Stephen K. ; Hughes, Thomas K. / Comprehensive analysis of genetic polymorphisms in the interleukin-10 promoter : Implications for immune regulation in specific ethnic populations. In: Genetic Testing. 2004 ; Vol. 8, No. 2. pp. 194-203.
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