Abstract
Since the India and Indian Ocean outbreaks of 2005 and 2006, the global distribution of chikungunya virus (CHIKV) and the locations of epidemics have dramatically shifted. First, the Indian Ocean lineage (IOL) caused sustained epidemics in India and has radiated to many other countries. Second, the Asian lineage has caused frequent outbreaks in the Pacific islands and in 2013 was introduced into the Caribbean, followed by rapid spread to nearly all of the neotropics. Further, CHIKV epidemics, as well as exported cases, have been reported in central Africa after a long period of perceived silence. To understand these changes and to anticipate the future of the virus, the exact distribution, genetic diversity, transmission routes, and future epidemic potential of CHIKV require further assessment. To do so, we conducted the most comprehensive phylogenetic analysis to date, examined CHIKV evolution and transmission, and explored distinct genetic factors associated with the emergence of the East/Central/ South African (ECSA) lineage, the IOL, and the Asian lineage. Our results reveal contrasting evolutionary patterns among the lineages, with growing genetic diversities observed in each, and suggest that CHIKV will continue to be a major public health threat with the potential for further emergence and spread.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10600-10611 |
| Number of pages | 12 |
| Journal | Journal of Virology |
| Volume | 90 |
| Issue number | 23 |
| DOIs | |
| State | Published - 2016 |
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ASJC Scopus subject areas
- Immunology
- Virology
Cite this
Comprehensive genome scale phylogenetic study provides new insights on the global expansion of chikungunya virus. / Chen, Rubing; Puri, Vinita; Fedorova, Nadia; Lin, David; Hari, Kumar L.; Jain, Ravi; Rodas, Juan David; Das, Suman R.; Shabman, Reed S.; Weaver, Scott.
In: Journal of Virology, Vol. 90, No. 23, 2016, p. 10600-10611.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comprehensive genome scale phylogenetic study provides new insights on the global expansion of chikungunya virus
AU - Chen, Rubing
AU - Puri, Vinita
AU - Fedorova, Nadia
AU - Lin, David
AU - Hari, Kumar L.
AU - Jain, Ravi
AU - Rodas, Juan David
AU - Das, Suman R.
AU - Shabman, Reed S.
AU - Weaver, Scott
PY - 2016
Y1 - 2016
N2 - Since the India and Indian Ocean outbreaks of 2005 and 2006, the global distribution of chikungunya virus (CHIKV) and the locations of epidemics have dramatically shifted. First, the Indian Ocean lineage (IOL) caused sustained epidemics in India and has radiated to many other countries. Second, the Asian lineage has caused frequent outbreaks in the Pacific islands and in 2013 was introduced into the Caribbean, followed by rapid spread to nearly all of the neotropics. Further, CHIKV epidemics, as well as exported cases, have been reported in central Africa after a long period of perceived silence. To understand these changes and to anticipate the future of the virus, the exact distribution, genetic diversity, transmission routes, and future epidemic potential of CHIKV require further assessment. To do so, we conducted the most comprehensive phylogenetic analysis to date, examined CHIKV evolution and transmission, and explored distinct genetic factors associated with the emergence of the East/Central/ South African (ECSA) lineage, the IOL, and the Asian lineage. Our results reveal contrasting evolutionary patterns among the lineages, with growing genetic diversities observed in each, and suggest that CHIKV will continue to be a major public health threat with the potential for further emergence and spread.
AB - Since the India and Indian Ocean outbreaks of 2005 and 2006, the global distribution of chikungunya virus (CHIKV) and the locations of epidemics have dramatically shifted. First, the Indian Ocean lineage (IOL) caused sustained epidemics in India and has radiated to many other countries. Second, the Asian lineage has caused frequent outbreaks in the Pacific islands and in 2013 was introduced into the Caribbean, followed by rapid spread to nearly all of the neotropics. Further, CHIKV epidemics, as well as exported cases, have been reported in central Africa after a long period of perceived silence. To understand these changes and to anticipate the future of the virus, the exact distribution, genetic diversity, transmission routes, and future epidemic potential of CHIKV require further assessment. To do so, we conducted the most comprehensive phylogenetic analysis to date, examined CHIKV evolution and transmission, and explored distinct genetic factors associated with the emergence of the East/Central/ South African (ECSA) lineage, the IOL, and the Asian lineage. Our results reveal contrasting evolutionary patterns among the lineages, with growing genetic diversities observed in each, and suggest that CHIKV will continue to be a major public health threat with the potential for further emergence and spread.
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UR - http://www.scopus.com/inward/citedby.url?scp=85000879020&partnerID=8YFLogxK
U2 - 10.1128/JVI.01166-16
DO - 10.1128/JVI.01166-16
M3 - Article
C2 - 27654297
AN - SCOPUS:85000879020
VL - 90
SP - 10600
EP - 10611
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 23
ER -