Comprehensive genome scale phylogenetic study provides new insights on the global expansion of chikungunya virus

Rubing Chen, Vinita Puri, Nadia Fedorova, David Lin, Kumar L. Hari, Ravi Jain, Juan David Rodas, Suman R. Das, Reed S. Shabman, Scott Weaver

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Since the India and Indian Ocean outbreaks of 2005 and 2006, the global distribution of chikungunya virus (CHIKV) and the locations of epidemics have dramatically shifted. First, the Indian Ocean lineage (IOL) caused sustained epidemics in India and has radiated to many other countries. Second, the Asian lineage has caused frequent outbreaks in the Pacific islands and in 2013 was introduced into the Caribbean, followed by rapid spread to nearly all of the neotropics. Further, CHIKV epidemics, as well as exported cases, have been reported in central Africa after a long period of perceived silence. To understand these changes and to anticipate the future of the virus, the exact distribution, genetic diversity, transmission routes, and future epidemic potential of CHIKV require further assessment. To do so, we conducted the most comprehensive phylogenetic analysis to date, examined CHIKV evolution and transmission, and explored distinct genetic factors associated with the emergence of the East/Central/ South African (ECSA) lineage, the IOL, and the Asian lineage. Our results reveal contrasting evolutionary patterns among the lineages, with growing genetic diversities observed in each, and suggest that CHIKV will continue to be a major public health threat with the potential for further emergence and spread.

Original languageEnglish (US)
Pages (from-to)10600-10611
Number of pages12
JournalJournal of Virology
Volume90
Issue number23
DOIs
StatePublished - 2016

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Chikungunya virus
Indian Ocean
Genome
genome
phylogeny
Disease Outbreaks
India
Pacific Islands
Central Africa
genetic variation
Pacific Ocean Islands
public health
Public Health
Viruses
viruses

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Comprehensive genome scale phylogenetic study provides new insights on the global expansion of chikungunya virus. / Chen, Rubing; Puri, Vinita; Fedorova, Nadia; Lin, David; Hari, Kumar L.; Jain, Ravi; Rodas, Juan David; Das, Suman R.; Shabman, Reed S.; Weaver, Scott.

In: Journal of Virology, Vol. 90, No. 23, 2016, p. 10600-10611.

Research output: Contribution to journalArticle

Chen, R, Puri, V, Fedorova, N, Lin, D, Hari, KL, Jain, R, Rodas, JD, Das, SR, Shabman, RS & Weaver, S 2016, 'Comprehensive genome scale phylogenetic study provides new insights on the global expansion of chikungunya virus', Journal of Virology, vol. 90, no. 23, pp. 10600-10611. https://doi.org/10.1128/JVI.01166-16
Chen, Rubing ; Puri, Vinita ; Fedorova, Nadia ; Lin, David ; Hari, Kumar L. ; Jain, Ravi ; Rodas, Juan David ; Das, Suman R. ; Shabman, Reed S. ; Weaver, Scott. / Comprehensive genome scale phylogenetic study provides new insights on the global expansion of chikungunya virus. In: Journal of Virology. 2016 ; Vol. 90, No. 23. pp. 10600-10611.
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