TY - JOUR
T1 - Comprehensive genome scale phylogenetic study provides new insights on the global expansion of chikungunya virus
AU - Chen, Rubing
AU - Puri, Vinita
AU - Fedorova, Nadia
AU - Lin, David
AU - Hari, Kumar L.
AU - Jain, Ravi
AU - Rodas, Juan David
AU - Das, Suman R.
AU - Shabman, Reed S.
AU - Weaver, Scott C.
N1 - Funding Information:
We thank Philippe Lemey and Edward Holmes for their advice and Mathilde Guerbois-Galla for technical help. This project was funded in part by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under awards AI120942, AI121452, and U19AI110819. Some of the genomes were sequenced with funding provided by DHS S&T through contract no. HSHQDC-13-C-B0009 (Capturing Global Biodiversity of Pathogens by Whole Genome Sequencing). The content is solely our responsibility and does not necessarily represent the official views of the National Institutes of Health. This work, including the efforts of David Lin, Kumar Hari, and Ravi Jain, was funded by Department of Homeland Security (HSHQDC-13-CB0009). This work, including the efforts of Rubing Chen, was funded by Department of Homeland Security (HSHQDC-13-C-B0009). This work, including the efforts of Scott C. Weaver, was funded by Department of Homeland Security (HSHQDC-13-C-B0009). This work, including the efforts of Scott C. Weaver, was funded by HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) (AI120942 and AI121452). This work, including the efforts of Rubing Chen, was funded by HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) (AI121452). This work, including the efforts of Vinita Puri and Nadia Fedorova, was funded by HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) (U19AI110819). This work, including the efforts of Suman R. Das and Reed S. Shabman, was funded by HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) (U19AI110819).
Publisher Copyright:
© 2016, American Society for Microbiology. All Rights Reserved.
PY - 2016
Y1 - 2016
N2 - Since the India and Indian Ocean outbreaks of 2005 and 2006, the global distribution of chikungunya virus (CHIKV) and the locations of epidemics have dramatically shifted. First, the Indian Ocean lineage (IOL) caused sustained epidemics in India and has radiated to many other countries. Second, the Asian lineage has caused frequent outbreaks in the Pacific islands and in 2013 was introduced into the Caribbean, followed by rapid spread to nearly all of the neotropics. Further, CHIKV epidemics, as well as exported cases, have been reported in central Africa after a long period of perceived silence. To understand these changes and to anticipate the future of the virus, the exact distribution, genetic diversity, transmission routes, and future epidemic potential of CHIKV require further assessment. To do so, we conducted the most comprehensive phylogenetic analysis to date, examined CHIKV evolution and transmission, and explored distinct genetic factors associated with the emergence of the East/Central/ South African (ECSA) lineage, the IOL, and the Asian lineage. Our results reveal contrasting evolutionary patterns among the lineages, with growing genetic diversities observed in each, and suggest that CHIKV will continue to be a major public health threat with the potential for further emergence and spread.
AB - Since the India and Indian Ocean outbreaks of 2005 and 2006, the global distribution of chikungunya virus (CHIKV) and the locations of epidemics have dramatically shifted. First, the Indian Ocean lineage (IOL) caused sustained epidemics in India and has radiated to many other countries. Second, the Asian lineage has caused frequent outbreaks in the Pacific islands and in 2013 was introduced into the Caribbean, followed by rapid spread to nearly all of the neotropics. Further, CHIKV epidemics, as well as exported cases, have been reported in central Africa after a long period of perceived silence. To understand these changes and to anticipate the future of the virus, the exact distribution, genetic diversity, transmission routes, and future epidemic potential of CHIKV require further assessment. To do so, we conducted the most comprehensive phylogenetic analysis to date, examined CHIKV evolution and transmission, and explored distinct genetic factors associated with the emergence of the East/Central/ South African (ECSA) lineage, the IOL, and the Asian lineage. Our results reveal contrasting evolutionary patterns among the lineages, with growing genetic diversities observed in each, and suggest that CHIKV will continue to be a major public health threat with the potential for further emergence and spread.
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U2 - 10.1128/JVI.01166-16
DO - 10.1128/JVI.01166-16
M3 - Article
C2 - 27654297
AN - SCOPUS:85000879020
VL - 90
SP - 10600
EP - 10611
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 23
ER -