TY - JOUR
T1 - Compromised Intestinal Barrier Resilience to Disruption in People With HIV
AU - Shaikh, Maliha W.
AU - Singh, Shalini
AU - Giron, Leila B.
AU - Zhang, Lijuan
AU - Shankaran, Shivanjali
AU - Engen, Phillip A.
AU - Villanueva, Michelle
AU - Sharma, Ashish Arunkumar
AU - Sekaly, Rafick Pierre
AU - Landay, Alan
AU - Keshavarzian, Ali
AU - Abdel-Mohsen, Mohamed
N1 - Publisher Copyright:
© The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved.
PY - 2025/8/15
Y1 - 2025/8/15
N2 - People with HIV (PWH) experience chronic intestinal barrier dysfunction, which contributes to chronic inflammation and its comorbidities. The mechanisms underlying this phenomenon remain unclear. We hypothesize that living with HIV compromises the intestinal barrier’s resilience to injurious agents, increasing susceptibility to leakage upon exposure to disruptors. Using intestinal organoids (colonoids and enteroids) derived from PWH and controls, we assessed the impact of alcohol and inflammatory cytokines on barrier integrity. Organoids from PWH exhibited reduced resilience to disruption compared to controls, correlating with alterations in pathways critical to epithelial integrity. These findings reveal a novel mechanism underlying intestinal dysfunction in PWH.
AB - People with HIV (PWH) experience chronic intestinal barrier dysfunction, which contributes to chronic inflammation and its comorbidities. The mechanisms underlying this phenomenon remain unclear. We hypothesize that living with HIV compromises the intestinal barrier’s resilience to injurious agents, increasing susceptibility to leakage upon exposure to disruptors. Using intestinal organoids (colonoids and enteroids) derived from PWH and controls, we assessed the impact of alcohol and inflammatory cytokines on barrier integrity. Organoids from PWH exhibited reduced resilience to disruption compared to controls, correlating with alterations in pathways critical to epithelial integrity. These findings reveal a novel mechanism underlying intestinal dysfunction in PWH.
KW - HIV
KW - gut
KW - inflammation
KW - intestinal barrier
KW - microbial translocation
UR - https://www.scopus.com/pages/publications/105010365753
UR - https://www.scopus.com/pages/publications/105010365753#tab=citedBy
U2 - 10.1093/infdis/jiaf119
DO - 10.1093/infdis/jiaf119
M3 - Article
C2 - 40048617
AN - SCOPUS:105010365753
SN - 0022-1899
VL - 232
SP - 364
EP - 369
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -