Computational drug repositioning for cancer therapeutics

Mingkun Jiao, Gang Liu, Yu Xue, Chunyong Ding

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Due to ever-increasing failure rates, high cost, unsatisfactory safety profile, and limited efficacy associated with anticancer drug development, the repositioning of established non-cancer drugs for new oncology indications has emerged as an increasingly attractive approach to addressing the unmet cancer-related medical need. With the rapid development of bioinformatics, chemoinformatics as well as high-performance computing, drug repositioning is becoming more intentional than ever, and a significant surge of computational approaches has been well established to greatly facilitate drug repositioning for cancer treatment. In this review, we provide a brief overview of recent advances in the computational drug repositioning for anticancer applications with a specific emphasis on repositioning of non-cancer drugs by use of various computational approaches.

Original languageEnglish (US)
Pages (from-to)767-775
Number of pages9
JournalCurrent Topics in Medicinal Chemistry
Volume15
Issue number8
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Drug Repositioning
Neoplasms
Computing Methodologies
Therapeutics
Computational Biology
Pharmaceutical Preparations
Safety
Costs and Cost Analysis

Keywords

  • Anticancer drugs
  • Cancer therapeutics
  • Computational drug repositioning
  • Drug discovery
  • Drug repositioning
  • Drug repurposing

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Computational drug repositioning for cancer therapeutics. / Jiao, Mingkun; Liu, Gang; Xue, Yu; Ding, Chunyong.

In: Current Topics in Medicinal Chemistry, Vol. 15, No. 8, 01.01.2015, p. 767-775.

Research output: Contribution to journalArticle

Jiao, Mingkun ; Liu, Gang ; Xue, Yu ; Ding, Chunyong. / Computational drug repositioning for cancer therapeutics. In: Current Topics in Medicinal Chemistry. 2015 ; Vol. 15, No. 8. pp. 767-775.
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