Concomitant Transmission of Dengue, Chikungunya, and Zika Viruses in Brazil: Clinical and Epidemiological Findings from Surveillance for Acute Febrile Illness

Monaíse M.O. Silva, Laura B. Tauro, Mariana Kikuti, Rosângela O. Anjos, Viviane C. Santos, Thaiza S.F. Gonçalves, Igor A.D. Paploski, Patrícia S.S. Moreira, Leile C.J. Nascimento, Gúbio S. Campos, Albert I. Ko, Scott C. Weaver, Mitermayer G. Reis, Uriel Kitron, Guilherme S. Ribeiro

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Since their emergence in the Americas, chikungunya (CHIKV) and Zika (ZIKV) viruses co-circulate with dengue virus (DENV), hampering clinical diagnosis. We investigated clinical and epidemiological characteristics of arboviral infections during the introduction and spread of CHIKV and ZIKV through northeastern Brazil. Methods: Surveillance for arboviral diseases among febrile patients was performed at an emergency health unit of Salvador, Brazil, between September 2014 and July 2016. We interviewed patients to collect data on symptoms, reviewed medical records to obtain the presumptive diagnoses, and performed molecular and serological testing to confirm DENV, CHIKV, ZIKV, or nonspecific flavivirus (FLAV) diagnosis. Results: Of 948 participants, 247 (26.1%) had an acute infection, of which 224 (23.6%) were single infections (DENV, 32 [3.4%]; CHIKV, 159 [16.7%]; ZIKV, 13 [1.4%]; and FLAV, 20 [2.1%]) and 23 (2.4%) coinfections (DENV/CHIKV, 13 [1.4%]; CHIKV/FLAV, 9 [0.9%]; and DENV/ZIKV, 1 [0.1%]). An additional 133 (14.0%) patients had serological evidence for a recent arboviral infection. Patients with ZIKV presented with rash and pruritus (69.2% each) more frequently than those with DENV (37.5% and 31.2%, respectively) and CHIKV (22.9% and 14.7%, respectively) (P <. 001 for both comparisons). Conversely, arthralgia was more common in CHIKV (94.9%) and FLAV/CHIKV (100.0%) than in DENV (59.4%) and ZIKV (53.8%) (P <. 001). A correct presumptive clinical diagnosis was made for 9%-23% of the confirmed patients. Conclusions: Arboviral infections are frequent causes of febrile illness. Coinfections are not rare events during periods of intense, concomitant arboviral transmission. Given the challenge to clinically distinguish these infections, there is an urgent need for rapid, point-of-care, multiplex diagnostics.

Original languageEnglish (US)
Pages (from-to)1353-1359
Number of pages7
JournalClinical Infectious Diseases
Volume69
Issue number8
DOIs
StatePublished - Sep 27 2019

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Chikungunya virus
Dengue Virus
Brazil
Fever
Flavivirus
Infection
Coinfection
Point-of-Care Systems
Arthralgia
Pruritus
Zika Virus
Exanthema
Medical Records
Hospital Emergency Service
Health

Keywords

  • arbovirus
  • chikungunya virus
  • coinfection
  • dengue virus
  • Zika virus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Concomitant Transmission of Dengue, Chikungunya, and Zika Viruses in Brazil : Clinical and Epidemiological Findings from Surveillance for Acute Febrile Illness. / Silva, Monaíse M.O.; Tauro, Laura B.; Kikuti, Mariana; Anjos, Rosângela O.; Santos, Viviane C.; Gonçalves, Thaiza S.F.; Paploski, Igor A.D.; Moreira, Patrícia S.S.; Nascimento, Leile C.J.; Campos, Gúbio S.; Ko, Albert I.; Weaver, Scott C.; Reis, Mitermayer G.; Kitron, Uriel; Ribeiro, Guilherme S.

In: Clinical Infectious Diseases, Vol. 69, No. 8, 27.09.2019, p. 1353-1359.

Research output: Contribution to journalArticle

Silva, MMO, Tauro, LB, Kikuti, M, Anjos, RO, Santos, VC, Gonçalves, TSF, Paploski, IAD, Moreira, PSS, Nascimento, LCJ, Campos, GS, Ko, AI, Weaver, SC, Reis, MG, Kitron, U & Ribeiro, GS 2019, 'Concomitant Transmission of Dengue, Chikungunya, and Zika Viruses in Brazil: Clinical and Epidemiological Findings from Surveillance for Acute Febrile Illness', Clinical Infectious Diseases, vol. 69, no. 8, pp. 1353-1359. https://doi.org/10.1093/cid/ciy1083
Silva, Monaíse M.O. ; Tauro, Laura B. ; Kikuti, Mariana ; Anjos, Rosângela O. ; Santos, Viviane C. ; Gonçalves, Thaiza S.F. ; Paploski, Igor A.D. ; Moreira, Patrícia S.S. ; Nascimento, Leile C.J. ; Campos, Gúbio S. ; Ko, Albert I. ; Weaver, Scott C. ; Reis, Mitermayer G. ; Kitron, Uriel ; Ribeiro, Guilherme S. / Concomitant Transmission of Dengue, Chikungunya, and Zika Viruses in Brazil : Clinical and Epidemiological Findings from Surveillance for Acute Febrile Illness. In: Clinical Infectious Diseases. 2019 ; Vol. 69, No. 8. pp. 1353-1359.
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abstract = "Background: Since their emergence in the Americas, chikungunya (CHIKV) and Zika (ZIKV) viruses co-circulate with dengue virus (DENV), hampering clinical diagnosis. We investigated clinical and epidemiological characteristics of arboviral infections during the introduction and spread of CHIKV and ZIKV through northeastern Brazil. Methods: Surveillance for arboviral diseases among febrile patients was performed at an emergency health unit of Salvador, Brazil, between September 2014 and July 2016. We interviewed patients to collect data on symptoms, reviewed medical records to obtain the presumptive diagnoses, and performed molecular and serological testing to confirm DENV, CHIKV, ZIKV, or nonspecific flavivirus (FLAV) diagnosis. Results: Of 948 participants, 247 (26.1{\%}) had an acute infection, of which 224 (23.6{\%}) were single infections (DENV, 32 [3.4{\%}]; CHIKV, 159 [16.7{\%}]; ZIKV, 13 [1.4{\%}]; and FLAV, 20 [2.1{\%}]) and 23 (2.4{\%}) coinfections (DENV/CHIKV, 13 [1.4{\%}]; CHIKV/FLAV, 9 [0.9{\%}]; and DENV/ZIKV, 1 [0.1{\%}]). An additional 133 (14.0{\%}) patients had serological evidence for a recent arboviral infection. Patients with ZIKV presented with rash and pruritus (69.2{\%} each) more frequently than those with DENV (37.5{\%} and 31.2{\%}, respectively) and CHIKV (22.9{\%} and 14.7{\%}, respectively) (P <. 001 for both comparisons). Conversely, arthralgia was more common in CHIKV (94.9{\%}) and FLAV/CHIKV (100.0{\%}) than in DENV (59.4{\%}) and ZIKV (53.8{\%}) (P <. 001). A correct presumptive clinical diagnosis was made for 9{\%}-23{\%} of the confirmed patients. Conclusions: Arboviral infections are frequent causes of febrile illness. Coinfections are not rare events during periods of intense, concomitant arboviral transmission. Given the challenge to clinically distinguish these infections, there is an urgent need for rapid, point-of-care, multiplex diagnostics.",
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TY - JOUR

T1 - Concomitant Transmission of Dengue, Chikungunya, and Zika Viruses in Brazil

T2 - Clinical and Epidemiological Findings from Surveillance for Acute Febrile Illness

AU - Silva, Monaíse M.O.

AU - Tauro, Laura B.

AU - Kikuti, Mariana

AU - Anjos, Rosângela O.

AU - Santos, Viviane C.

AU - Gonçalves, Thaiza S.F.

AU - Paploski, Igor A.D.

AU - Moreira, Patrícia S.S.

AU - Nascimento, Leile C.J.

AU - Campos, Gúbio S.

AU - Ko, Albert I.

AU - Weaver, Scott C.

AU - Reis, Mitermayer G.

AU - Kitron, Uriel

AU - Ribeiro, Guilherme S.

PY - 2019/9/27

Y1 - 2019/9/27

N2 - Background: Since their emergence in the Americas, chikungunya (CHIKV) and Zika (ZIKV) viruses co-circulate with dengue virus (DENV), hampering clinical diagnosis. We investigated clinical and epidemiological characteristics of arboviral infections during the introduction and spread of CHIKV and ZIKV through northeastern Brazil. Methods: Surveillance for arboviral diseases among febrile patients was performed at an emergency health unit of Salvador, Brazil, between September 2014 and July 2016. We interviewed patients to collect data on symptoms, reviewed medical records to obtain the presumptive diagnoses, and performed molecular and serological testing to confirm DENV, CHIKV, ZIKV, or nonspecific flavivirus (FLAV) diagnosis. Results: Of 948 participants, 247 (26.1%) had an acute infection, of which 224 (23.6%) were single infections (DENV, 32 [3.4%]; CHIKV, 159 [16.7%]; ZIKV, 13 [1.4%]; and FLAV, 20 [2.1%]) and 23 (2.4%) coinfections (DENV/CHIKV, 13 [1.4%]; CHIKV/FLAV, 9 [0.9%]; and DENV/ZIKV, 1 [0.1%]). An additional 133 (14.0%) patients had serological evidence for a recent arboviral infection. Patients with ZIKV presented with rash and pruritus (69.2% each) more frequently than those with DENV (37.5% and 31.2%, respectively) and CHIKV (22.9% and 14.7%, respectively) (P <. 001 for both comparisons). Conversely, arthralgia was more common in CHIKV (94.9%) and FLAV/CHIKV (100.0%) than in DENV (59.4%) and ZIKV (53.8%) (P <. 001). A correct presumptive clinical diagnosis was made for 9%-23% of the confirmed patients. Conclusions: Arboviral infections are frequent causes of febrile illness. Coinfections are not rare events during periods of intense, concomitant arboviral transmission. Given the challenge to clinically distinguish these infections, there is an urgent need for rapid, point-of-care, multiplex diagnostics.

AB - Background: Since their emergence in the Americas, chikungunya (CHIKV) and Zika (ZIKV) viruses co-circulate with dengue virus (DENV), hampering clinical diagnosis. We investigated clinical and epidemiological characteristics of arboviral infections during the introduction and spread of CHIKV and ZIKV through northeastern Brazil. Methods: Surveillance for arboviral diseases among febrile patients was performed at an emergency health unit of Salvador, Brazil, between September 2014 and July 2016. We interviewed patients to collect data on symptoms, reviewed medical records to obtain the presumptive diagnoses, and performed molecular and serological testing to confirm DENV, CHIKV, ZIKV, or nonspecific flavivirus (FLAV) diagnosis. Results: Of 948 participants, 247 (26.1%) had an acute infection, of which 224 (23.6%) were single infections (DENV, 32 [3.4%]; CHIKV, 159 [16.7%]; ZIKV, 13 [1.4%]; and FLAV, 20 [2.1%]) and 23 (2.4%) coinfections (DENV/CHIKV, 13 [1.4%]; CHIKV/FLAV, 9 [0.9%]; and DENV/ZIKV, 1 [0.1%]). An additional 133 (14.0%) patients had serological evidence for a recent arboviral infection. Patients with ZIKV presented with rash and pruritus (69.2% each) more frequently than those with DENV (37.5% and 31.2%, respectively) and CHIKV (22.9% and 14.7%, respectively) (P <. 001 for both comparisons). Conversely, arthralgia was more common in CHIKV (94.9%) and FLAV/CHIKV (100.0%) than in DENV (59.4%) and ZIKV (53.8%) (P <. 001). A correct presumptive clinical diagnosis was made for 9%-23% of the confirmed patients. Conclusions: Arboviral infections are frequent causes of febrile illness. Coinfections are not rare events during periods of intense, concomitant arboviral transmission. Given the challenge to clinically distinguish these infections, there is an urgent need for rapid, point-of-care, multiplex diagnostics.

KW - arbovirus

KW - chikungunya virus

KW - coinfection

KW - dengue virus

KW - Zika virus

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