Concurrent cetuximab and postoperative radiation in resected high-risk squamous cell carcinomas of the head and neck: A single-institution experience

Daisuke Araki, Mary W. Redman, Renato Martins, Keith Eaton, Christina Baik, Laura Chow, Bernardo Goulart, Sylvia Lee, Rafael Santana–Davila, Jay Liao, Upendra Parvathaneni, George Laramore, Neal Futran, Eduardo Mendez, Amit Bhrany, Cristina P. Rodriguez

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: Postoperative cisplatin and radiation is the standard of care for high-risk squamous cell carcinoma of the head and neck (SCCHN). We have used cetuximab and radiation in the postoperative setting for patients deemed poor candidates for cisplatin. Methods: We retrospectively identified 40 patients who received cetuximab and radiation for resected locoregionally advanced SCCHN between 2006 and 2013 at our institution. Results: The 2-year Kaplan–Meier estimates were: overall survival (OS) 41%, recurrence-free survival (RFS) 34%, locoregional control 63%, and distant metastatic control 59%. Eastern Cooperative Oncology Group (ECOG) performance status ≥1 predicted for inferior OS (hazard ratio [HR] = 5.43; p =.003), RFS (HR = 4.07; p =.007), and locoregional control (HR = 4.92; p =.04) in multivariate analysis. Conclusion: Patients with resected high-risk SCCHN treated with postoperative cetuximab and radiation have suboptimal therapeutic outcomes. Further study of the efficacy and cost-effectiveness compared to radiation alone is warranted.

Original languageEnglish (US)
Pages (from-to)1318-1323
Number of pages6
JournalHead and Neck
Volume38
Issue number9
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • cetuximab
  • high-risk features
  • locoregionally advanced
  • postoperative radiation
  • squamous cell carcinoma of the head and neck

ASJC Scopus subject areas

  • Otorhinolaryngology

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