Abstract
Background: Postoperative cisplatin and radiation is the standard of care for high-risk squamous cell carcinoma of the head and neck (SCCHN). We have used cetuximab and radiation in the postoperative setting for patients deemed poor candidates for cisplatin. Methods: We retrospectively identified 40 patients who received cetuximab and radiation for resected locoregionally advanced SCCHN between 2006 and 2013 at our institution. Results: The 2-year Kaplan–Meier estimates were: overall survival (OS) 41%, recurrence-free survival (RFS) 34%, locoregional control 63%, and distant metastatic control 59%. Eastern Cooperative Oncology Group (ECOG) performance status ≥1 predicted for inferior OS (hazard ratio [HR] = 5.43; p =.003), RFS (HR = 4.07; p =.007), and locoregional control (HR = 4.92; p =.04) in multivariate analysis. Conclusion: Patients with resected high-risk SCCHN treated with postoperative cetuximab and radiation have suboptimal therapeutic outcomes. Further study of the efficacy and cost-effectiveness compared to radiation alone is warranted.
Original language | English (US) |
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Pages (from-to) | 1318-1323 |
Number of pages | 6 |
Journal | Head and Neck |
Volume | 38 |
Issue number | 9 |
DOIs | |
State | Published - 2016 |
Externally published | Yes |
Keywords
- cetuximab
- high-risk features
- locoregionally advanced
- postoperative radiation
- squamous cell carcinoma of the head and neck
ASJC Scopus subject areas
- Otorhinolaryngology