Concurrent lupus anticoagulants and prothrombin defiency due to phenytoin use

R. L. Harrison, J. B. Alperin, D. Kumar

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A man with a lupus anticoagulant and a prothrombin deficiency was studied before and after cessation of treatment with phenytoin. Multiple abnormal laboratory values of the following partially or completely resolved after the patient's therapy was discontinued: tissue thromboplastin inhibition ratio, prothrombin time, activated partial thromboplastin time, anticardiolipin antibodies, and quantitative measures and abnormal pattern on crossed immunoelectrophoresis of prothrombin. This patient represented an example of a concurrent drug-induced prothrombin deficiency and a lupus anticoagulant.

Original languageEnglish (US)
Pages (from-to)719-722
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume111
Issue number8
StatePublished - 1987

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Hypoprothrombinemias
Lupus Coagulation Inhibitor
Phenytoin
Prothrombin
Two-Dimensional Immunoelectrophoresis
Anticardiolipin Antibodies
Withholding Treatment
Partial Thromboplastin Time
Prothrombin Time
Thromboplastin
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Concurrent lupus anticoagulants and prothrombin defiency due to phenytoin use. / Harrison, R. L.; Alperin, J. B.; Kumar, D.

In: Archives of Pathology and Laboratory Medicine, Vol. 111, No. 8, 1987, p. 719-722.

Research output: Contribution to journalArticle

Harrison, R. L. ; Alperin, J. B. ; Kumar, D. / Concurrent lupus anticoagulants and prothrombin defiency due to phenytoin use. In: Archives of Pathology and Laboratory Medicine. 1987 ; Vol. 111, No. 8. pp. 719-722.
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