Conditional survival for pediatric and adolescent patients with cancer: Implications for survivorship care

Sapna Kaul, Anne C. Kirchhoff, Kenneth M. Boucher, Andrew C. Dietz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Few studies have evaluated conditional survival (probability of surviving y years given patients have already survived x years) for pediatric/adolescent patients diagnosed with cancer. To provide more accurate information on ongoing survival, we evaluate conditional survival for pediatric and adolescent patients with cancer. Methods: The statewide Utah Cancer Registry identified 3344 patients born in Utah diagnosed with cancer at ages 0-21 years, from 1973 to 2009. The Utah Population Database provided demographic information. We estimated five-year conditional survival at diagnosis, and one and three years after diagnosis, by risk factors such as cancer type, sex, diagnosis age and treatment era (1973-1994 vs. 1995-2009). Results: Conditional survival estimates at one (85.1%, 95% CI: 83.7-86.5) and three years (92.9%, 95% CI: 91.8-93.9) after diagnosis were significantly higher than survival at diagnosis (77.2%, 95% CI: 75.6-78.9), although results varied by cancer type and initial prognosis. Diagnosis age affected survival for cancers where age is a risk factor. For example, five-year survival at one year after diagnosis was higher for younger (≤18 months of age) patients compared to older (>18 months) patients with neuroblastoma (95.4%, 95% CI: 90.9-99.9 vs. 56.8%, 95% CI: 41.8-71.7, p<0.001). Conditional survival improved over time for many cancers. Minimal differences were observed by sex. Conclusion: Substantial improvements were observed in conditional survival at one and three years after diagnosis compared with survival at diagnosis. Several risk factors affected these outcomes. Clearer understandings of survival will help in administering effective survivorship care and decreasing prognosis-related anxiety/stress for patients and families.

Original languageEnglish (US)
Pages (from-to)1071-1077
Number of pages7
JournalCancer Epidemiology
Volume39
Issue number6
DOIs
StatePublished - Dec 1 2015

Fingerprint

Survival Rate
Pediatrics
Survival
Neoplasms
Neuroblastoma
Registries
Anxiety
Demography
Databases

Keywords

  • Adolescent cancer
  • Conditional survival
  • Pediatric cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology

Cite this

Conditional survival for pediatric and adolescent patients with cancer : Implications for survivorship care. / Kaul, Sapna; Kirchhoff, Anne C.; Boucher, Kenneth M.; Dietz, Andrew C.

In: Cancer Epidemiology, Vol. 39, No. 6, 01.12.2015, p. 1071-1077.

Research output: Contribution to journalArticle

Kaul, Sapna ; Kirchhoff, Anne C. ; Boucher, Kenneth M. ; Dietz, Andrew C. / Conditional survival for pediatric and adolescent patients with cancer : Implications for survivorship care. In: Cancer Epidemiology. 2015 ; Vol. 39, No. 6. pp. 1071-1077.
@article{61d83c7eaa2f43f6a35be923c3190e4e,
title = "Conditional survival for pediatric and adolescent patients with cancer: Implications for survivorship care",
abstract = "Purpose: Few studies have evaluated conditional survival (probability of surviving y years given patients have already survived x years) for pediatric/adolescent patients diagnosed with cancer. To provide more accurate information on ongoing survival, we evaluate conditional survival for pediatric and adolescent patients with cancer. Methods: The statewide Utah Cancer Registry identified 3344 patients born in Utah diagnosed with cancer at ages 0-21 years, from 1973 to 2009. The Utah Population Database provided demographic information. We estimated five-year conditional survival at diagnosis, and one and three years after diagnosis, by risk factors such as cancer type, sex, diagnosis age and treatment era (1973-1994 vs. 1995-2009). Results: Conditional survival estimates at one (85.1{\%}, 95{\%} CI: 83.7-86.5) and three years (92.9{\%}, 95{\%} CI: 91.8-93.9) after diagnosis were significantly higher than survival at diagnosis (77.2{\%}, 95{\%} CI: 75.6-78.9), although results varied by cancer type and initial prognosis. Diagnosis age affected survival for cancers where age is a risk factor. For example, five-year survival at one year after diagnosis was higher for younger (≤18 months of age) patients compared to older (>18 months) patients with neuroblastoma (95.4{\%}, 95{\%} CI: 90.9-99.9 vs. 56.8{\%}, 95{\%} CI: 41.8-71.7, p<0.001). Conditional survival improved over time for many cancers. Minimal differences were observed by sex. Conclusion: Substantial improvements were observed in conditional survival at one and three years after diagnosis compared with survival at diagnosis. Several risk factors affected these outcomes. Clearer understandings of survival will help in administering effective survivorship care and decreasing prognosis-related anxiety/stress for patients and families.",
keywords = "Adolescent cancer, Conditional survival, Pediatric cancer",
author = "Sapna Kaul and Kirchhoff, {Anne C.} and Boucher, {Kenneth M.} and Dietz, {Andrew C.}",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/j.canep.2015.09.006",
language = "English (US)",
volume = "39",
pages = "1071--1077",
journal = "Cancer Epidemiology",
issn = "1877-7821",
publisher = "Elsevier BV",
number = "6",

}

TY - JOUR

T1 - Conditional survival for pediatric and adolescent patients with cancer

T2 - Implications for survivorship care

AU - Kaul, Sapna

AU - Kirchhoff, Anne C.

AU - Boucher, Kenneth M.

AU - Dietz, Andrew C.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Purpose: Few studies have evaluated conditional survival (probability of surviving y years given patients have already survived x years) for pediatric/adolescent patients diagnosed with cancer. To provide more accurate information on ongoing survival, we evaluate conditional survival for pediatric and adolescent patients with cancer. Methods: The statewide Utah Cancer Registry identified 3344 patients born in Utah diagnosed with cancer at ages 0-21 years, from 1973 to 2009. The Utah Population Database provided demographic information. We estimated five-year conditional survival at diagnosis, and one and three years after diagnosis, by risk factors such as cancer type, sex, diagnosis age and treatment era (1973-1994 vs. 1995-2009). Results: Conditional survival estimates at one (85.1%, 95% CI: 83.7-86.5) and three years (92.9%, 95% CI: 91.8-93.9) after diagnosis were significantly higher than survival at diagnosis (77.2%, 95% CI: 75.6-78.9), although results varied by cancer type and initial prognosis. Diagnosis age affected survival for cancers where age is a risk factor. For example, five-year survival at one year after diagnosis was higher for younger (≤18 months of age) patients compared to older (>18 months) patients with neuroblastoma (95.4%, 95% CI: 90.9-99.9 vs. 56.8%, 95% CI: 41.8-71.7, p<0.001). Conditional survival improved over time for many cancers. Minimal differences were observed by sex. Conclusion: Substantial improvements were observed in conditional survival at one and three years after diagnosis compared with survival at diagnosis. Several risk factors affected these outcomes. Clearer understandings of survival will help in administering effective survivorship care and decreasing prognosis-related anxiety/stress for patients and families.

AB - Purpose: Few studies have evaluated conditional survival (probability of surviving y years given patients have already survived x years) for pediatric/adolescent patients diagnosed with cancer. To provide more accurate information on ongoing survival, we evaluate conditional survival for pediatric and adolescent patients with cancer. Methods: The statewide Utah Cancer Registry identified 3344 patients born in Utah diagnosed with cancer at ages 0-21 years, from 1973 to 2009. The Utah Population Database provided demographic information. We estimated five-year conditional survival at diagnosis, and one and three years after diagnosis, by risk factors such as cancer type, sex, diagnosis age and treatment era (1973-1994 vs. 1995-2009). Results: Conditional survival estimates at one (85.1%, 95% CI: 83.7-86.5) and three years (92.9%, 95% CI: 91.8-93.9) after diagnosis were significantly higher than survival at diagnosis (77.2%, 95% CI: 75.6-78.9), although results varied by cancer type and initial prognosis. Diagnosis age affected survival for cancers where age is a risk factor. For example, five-year survival at one year after diagnosis was higher for younger (≤18 months of age) patients compared to older (>18 months) patients with neuroblastoma (95.4%, 95% CI: 90.9-99.9 vs. 56.8%, 95% CI: 41.8-71.7, p<0.001). Conditional survival improved over time for many cancers. Minimal differences were observed by sex. Conclusion: Substantial improvements were observed in conditional survival at one and three years after diagnosis compared with survival at diagnosis. Several risk factors affected these outcomes. Clearer understandings of survival will help in administering effective survivorship care and decreasing prognosis-related anxiety/stress for patients and families.

KW - Adolescent cancer

KW - Conditional survival

KW - Pediatric cancer

UR - http://www.scopus.com/inward/record.url?scp=84951568456&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84951568456&partnerID=8YFLogxK

U2 - 10.1016/j.canep.2015.09.006

DO - 10.1016/j.canep.2015.09.006

M3 - Article

C2 - 26427865

AN - SCOPUS:84951568456

VL - 39

SP - 1071

EP - 1077

JO - Cancer Epidemiology

JF - Cancer Epidemiology

SN - 1877-7821

IS - 6

ER -