Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

Aseem Mishra, Anurag Misra, T. Sri Vaishnavi, Chaitanya Thota, Madhvi Gupta, Suryanarayanarao Ramakumar, Virander Singh Chauhan

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects β-cells from hIAPP induced toxicity.

Original languageEnglish (US)
Pages (from-to)2688-2690
Number of pages3
JournalChemical Communications
Volume49
Issue number26
DOIs
StatePublished - Apr 4 2013
Externally publishedYes

Fingerprint

Islet Amyloid Polypeptide
Polypeptides
Peptides
Poisons
Insulin
Pathology
Medical problems
Oligomers
Toxicity
Amyloid

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Mishra, A., Misra, A., Sri Vaishnavi, T., Thota, C., Gupta, M., Ramakumar, S., & Chauhan, V. S. (2013). Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization. Chemical Communications, 49(26), 2688-2690. https://doi.org/10.1039/c3cc38982k

Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization. / Mishra, Aseem; Misra, Anurag; Sri Vaishnavi, T.; Thota, Chaitanya; Gupta, Madhvi; Ramakumar, Suryanarayanarao; Chauhan, Virander Singh.

In: Chemical Communications, Vol. 49, No. 26, 04.04.2013, p. 2688-2690.

Research output: Contribution to journalArticle

Mishra, A, Misra, A, Sri Vaishnavi, T, Thota, C, Gupta, M, Ramakumar, S & Chauhan, VS 2013, 'Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization', Chemical Communications, vol. 49, no. 26, pp. 2688-2690. https://doi.org/10.1039/c3cc38982k
Mishra, Aseem ; Misra, Anurag ; Sri Vaishnavi, T. ; Thota, Chaitanya ; Gupta, Madhvi ; Ramakumar, Suryanarayanarao ; Chauhan, Virander Singh. / Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization. In: Chemical Communications. 2013 ; Vol. 49, No. 26. pp. 2688-2690.
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