Abstract
The classification of posterior fossa congenital anomalies has been a controversial topic. Advances in genetics and imaging have allowed a better understanding of the embryologic development of these abnormalities. A new classification schema correlates the embryologic, morphologic, and genetic bases of these anomalies in order to better distinguish and describe them. Although they provide a better understanding of the clinical aspects and genetics of these disorders, it is crucial for the radiologist to be able to diagnose the congenital posterior fossa anomalies based on their morphology, since neuroimaging is usually the initial step when these disorders are suspected. We divide the most common posterior fossa congenital anomalies into two groups: 1) hindbrain malformations, including diseases with cerebellar or vermian agenesis, aplasia or hypoplasia and cystic posterior fossa anomalies; and 2) cranial vault malformations. In addition, we will review the embryologic development of the posterior fossa and, from the perspective of embryonic development, will describe the imaging appearance of congenital posterior fossa anomalies. Knowledge of the developmental bases of these malformations facilitates detection of the morphological changes identified on imaging, allowing accurate differentiation and diagnosis of congenital posterior fossa anomalies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 238-253 |
| Number of pages | 16 |
| Journal | Neuroradiology Journal |
| Volume | 28 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 1 2015 |
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Keywords
- Congenital posterior fossa abnormalities
- Development posterior fossa
- Embryology posterior fossa
- Imaging posterior fossa
- Posterior fossa anomalies
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology
Cite this
Congenital basis of posterior fossa anomalies. / Cotes, Claudia; Bonfante, Eliana; Lazor, Jillian; Jadhav, Siddharth; Caldas, Maria; Swischuk, Leonard; Riascos, Roy.
In: Neuroradiology Journal, Vol. 28, No. 3, 01.06.2015, p. 238-253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Congenital basis of posterior fossa anomalies
AU - Cotes, Claudia
AU - Bonfante, Eliana
AU - Lazor, Jillian
AU - Jadhav, Siddharth
AU - Caldas, Maria
AU - Swischuk, Leonard
AU - Riascos, Roy
PY - 2015/6/1
Y1 - 2015/6/1
N2 - The classification of posterior fossa congenital anomalies has been a controversial topic. Advances in genetics and imaging have allowed a better understanding of the embryologic development of these abnormalities. A new classification schema correlates the embryologic, morphologic, and genetic bases of these anomalies in order to better distinguish and describe them. Although they provide a better understanding of the clinical aspects and genetics of these disorders, it is crucial for the radiologist to be able to diagnose the congenital posterior fossa anomalies based on their morphology, since neuroimaging is usually the initial step when these disorders are suspected. We divide the most common posterior fossa congenital anomalies into two groups: 1) hindbrain malformations, including diseases with cerebellar or vermian agenesis, aplasia or hypoplasia and cystic posterior fossa anomalies; and 2) cranial vault malformations. In addition, we will review the embryologic development of the posterior fossa and, from the perspective of embryonic development, will describe the imaging appearance of congenital posterior fossa anomalies. Knowledge of the developmental bases of these malformations facilitates detection of the morphological changes identified on imaging, allowing accurate differentiation and diagnosis of congenital posterior fossa anomalies.
AB - The classification of posterior fossa congenital anomalies has been a controversial topic. Advances in genetics and imaging have allowed a better understanding of the embryologic development of these abnormalities. A new classification schema correlates the embryologic, morphologic, and genetic bases of these anomalies in order to better distinguish and describe them. Although they provide a better understanding of the clinical aspects and genetics of these disorders, it is crucial for the radiologist to be able to diagnose the congenital posterior fossa anomalies based on their morphology, since neuroimaging is usually the initial step when these disorders are suspected. We divide the most common posterior fossa congenital anomalies into two groups: 1) hindbrain malformations, including diseases with cerebellar or vermian agenesis, aplasia or hypoplasia and cystic posterior fossa anomalies; and 2) cranial vault malformations. In addition, we will review the embryologic development of the posterior fossa and, from the perspective of embryonic development, will describe the imaging appearance of congenital posterior fossa anomalies. Knowledge of the developmental bases of these malformations facilitates detection of the morphological changes identified on imaging, allowing accurate differentiation and diagnosis of congenital posterior fossa anomalies.
KW - Congenital posterior fossa abnormalities
KW - Development posterior fossa
KW - Embryology posterior fossa
KW - Imaging posterior fossa
KW - Posterior fossa anomalies
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U2 - 10.1177/1971400915576665
DO - 10.1177/1971400915576665
M3 - Article
VL - 28
SP - 238
EP - 253
JO - Neuroradiology Journal
JF - Neuroradiology Journal
SN - 1971-4009
IS - 3
ER -