Congenital transmission of experimental leishmaniasis in a hamster model

Elvia Yaneth Osorio, Luz D. Rodriguez, Diana L. Bonilla, Alex-Giovanny Peniche-Trujillo, Hector Henao, Omar Saldarriaga, Bruno Travi

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11 Citations (Scopus)

Abstract

Little information is available on transplacental transmission of Leishmania spp. We determined the frequency and impact of congenital infection caused by Leishmania panamensis or L. donovani in experimentally infected hamsters. A polymerase chain reaction showed that congenital transmission occurred in 25.8% (24 of 93) of offspring born to L. panamensis-infected hamsters and 14.6% (11 of 75) offspring born to L. donovani-infected hamsters. Mortality during lactation was higher in offspring born to L. panamensis-infected hamsters and offspring born to L. donovani-infected hamsters than controls, and lymphoproliferation to Leishmania was more frequent in offspring born to L. panamensis-infected hamsters (17.4%, 11 of 63) than in offspring born to L. donovani-infected hamsters (8.5%, 3 of 35). After weaning, only offspring born to L. donovani-infected hamsters had lower weight gain (P < 0.001) and hematocrit levels (P = 0.0045) than controls. Challenge of offspring born to L. panamensis-infected hamsters with L. panamensis showed no differences in lesion evolution, and offspring born to L. donovani-infected hamsters were more susceptible to L. donovani challenge than controls. Consequently, prenatal exposure of hamsters to L. donovani significantly increased the mortality risk and susceptibility to secondary homologous infection.

Original languageEnglish (US)
Pages (from-to)812-820
Number of pages9
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume86
Issue number5
DOIs
StatePublished - May 2012

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Leishmaniasis
Cricetinae
Leishmania
Mortality
Weaning
Coinfection
Hematocrit
Lactation
Weight Gain

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Congenital transmission of experimental leishmaniasis in a hamster model. / Osorio, Elvia Yaneth; Rodriguez, Luz D.; Bonilla, Diana L.; Peniche-Trujillo, Alex-Giovanny; Henao, Hector; Saldarriaga, Omar; Travi, Bruno.

In: American Journal of Tropical Medicine and Hygiene, Vol. 86, No. 5, 05.2012, p. 812-820.

Research output: Contribution to journalArticle

Osorio, Elvia Yaneth ; Rodriguez, Luz D. ; Bonilla, Diana L. ; Peniche-Trujillo, Alex-Giovanny ; Henao, Hector ; Saldarriaga, Omar ; Travi, Bruno. / Congenital transmission of experimental leishmaniasis in a hamster model. In: American Journal of Tropical Medicine and Hygiene. 2012 ; Vol. 86, No. 5. pp. 812-820.
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