Construction of stable reporter flaviviruses and their applications

Coleman Baker, Pei Yong Shi

Research output: Contribution to journalArticlepeer-review

Abstract

Flaviviruses are significant human pathogens that cause frequent emerging and reemerging epidemics around the world. Better molecular tools for studying, diagnosing, and treating these diseases are needed. Reporter viruses represent potent tools to fill this gap but have been hindered by genetic instability. Recent advances have overcome these hurdles, opening the way for increased use of stable reporter flaviviruses to diagnose infections, screen and study antiviral compounds, and serve as potential vaccine vectors.

Original languageEnglish (US)
Article number1082
JournalViruses
Volume12
Issue number10
DOIs
StatePublished - Oct 2020

Keywords

  • Emerging viruses
  • RNA
  • RNA viruses
  • Reporter viruses
  • Zoonosis

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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