Continuous infusion of levodopa-carbidopa intestinal gel in Parkinson's disease

Lalitha N. Guthikonda, Kelly E. Lyons, Rajesh Pahwa

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Evaluation of: Olanow CW, Kieburtz K, Odin P et al. Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study. Lancet Neurol. 13(2), 141-149 (2014). Levodopa-induced motor complications, including motor fluctuations and dyskinesia, can be a major source of disability for Parkinson's disease patients. The development of levodopa-induced motor complications has been attributed to the pulsatile dopaminergic stimulation characteristic of conventional oral levodopa regimens. This is a review of a 12-week, randomized, controlled, double-blind, double-dummy study of continuous jejunal infusion of levodopa-carbidopa intestinal gel to determine if the continuous infusion of levodopa reduces motor complications in Parkinson's disease. Results demonstrated that levodopa-carbidopa intestinal gel significantly reduced off-time without increasing troublesome dyskinesia compared with standard oral levodopa therapy. Adverse effects were common in both the levodopa-carbidopa intestinal gel and placebo groups and were related primarily to the infusion hardware.

Original languageEnglish (US)
Pages (from-to)331-333
Number of pages3
JournalJournal of Comparative Effectiveness Research
Volume3
Issue number4
DOIs
StatePublished - Jul 1 2014

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Keywords

  • LCIG
  • Parkinson's disease
  • continuous drug infusion
  • dyskinesia
  • levodopa-carbidopa intestinal gel
  • motor fluctuations

ASJC Scopus subject areas

  • Health Policy

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