Continuous membrane-cytoskeleton adhesion requires continuous accommodation to lipid and cytoskeleton dynamics

Michael Sheetz, Julia E. Sable, Hans Günther Döbereiner

Research output: Contribution to journalReview article

203 Citations (Scopus)

Abstract

The plasma membrane of most animal cells conforms to the cytoskeleton and only occasionally separates to form blebs. Previous studies indicated that many weak interactions between cytoskeleton and the lipid bilayer kept the surfaces together to counteract the normal outward pressure of cytoplasm. Either the loss of adhesion strength or the formation of gaps in the cytoskeleton enables the pressure to form blebs. Membrane-associated cytoskeleton proteins, such as spectrin and filamin, can control the movement and aggregation of membrane proteins and lipids, e.g., phosphoinositol phospholipids (PIPs), as well as blebbing. At the same time, lipids (particularly PIPs) and membrane proteins affect cytoskeleton and signaling dynamics. We consider here the roles of the major phosphatidylinositol-4,5-diphosphate (PIP2) binding protein, MARCKS, and PIP2 levels in controlling cytoskeleton dynamics. Further understanding of dynamics will provide important clues about how membrane-cytoskeleton adhesion rapidly adjusts to cytoskeleton and membrane dynamics.

Original languageEnglish (US)
Pages (from-to)417-434
Number of pages18
JournalAnnual Review of Biophysics and Biomolecular Structure
Volume35
DOIs
StatePublished - Jun 19 2006
Externally publishedYes

Fingerprint

Cytoskeleton
Lipids
Adhesion
Membranes
Phospholipids
Membrane Proteins
Proteins
Blister
Phosphatidylinositol 4,5-Diphosphate
Filamins
Spectrin
Lipid bilayers
Bond strength (materials)
Cell membranes
Membrane Lipids
Carrier Proteins
Animals
Agglomeration
Cells
Pressure

Keywords

  • Actin cytoskeleton
  • Membrane blebs
  • Membrane tension
  • Membrane tethers
  • Phosphatidylinositol-4,5-diphosphate (PIP2)
  • Spectrin

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology

Cite this

Continuous membrane-cytoskeleton adhesion requires continuous accommodation to lipid and cytoskeleton dynamics. / Sheetz, Michael; Sable, Julia E.; Döbereiner, Hans Günther.

In: Annual Review of Biophysics and Biomolecular Structure, Vol. 35, 19.06.2006, p. 417-434.

Research output: Contribution to journalReview article

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AU - Sable, Julia E.

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