Continuous nebulized albuterol attenuates acute lung injury in an ovine model of combined burn and smoke inhalation

Tina L. Palmieri, Perenlei Enkhbaatar, Robert Bayliss, Lillian D. Traber, Robert A. Cox, Hal K. Hawkins, David Herndon, David G. Greenhalgh, Daniel L. Traber

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

OBJECTIVE: Albuterol, due to its bronchodilatory and anti-inflammatory effects, is given via continuous nebulization in children with severe asthma. Combined burn and smoke inhalation injury frequently results in acute lung injury due to a combination of airway obstruction and inflammation. We hypothesized that albuterol administered via continuous nebulization would mitigate acute lung injury after smoke inhalation injury and burn. DESIGN: Randomized prospective animal model. SUBJECTS: Twenty adult female sheep (mean weight, 33.1 ± 0.9 kg). INTERVENTIONS: Adult ewes were subjected to a 40% body surface area third-degree flame burn and smoke inhalation injury after tracheostomy. Sheep were allocated to a) sham group, b) saline continuous nebulization group, c) 20 mg of albuterol continuous nebulization group, or d) 40 mg of albuterol continuous nebulization group (n = 5 animals per group). All groups received intravenous lactated Ringer's solution at 4 mL • kg • %burn • 24 hrs for resuscitation and were equally mechanically ventilated throughout the 48-hr study period. Pulmonary and cardiac function, lung lymph flow, bronchial obstruction score, and wet/dry lung weights were recorded. RESULTS: Compared with saline and control groups, the albuterol groups had lower pause and peak inspiratory pressures, decreased pulmonary transvascular fluid flux, a significantly higher Pao2/Fio2 ratio, and decreased shunt fraction at 48 hrs postinjury. The wet-to-dry lung weight ratio and bronchial obstruction scores were lower for sheep receiving albuterol. CONCLUSIONS: Continuous nebulization of albuterol improves pulmonary function via improved airway clearance and decreased fluid flux in a combined burn/smoke inhalation injury model.

Original languageEnglish (US)
Pages (from-to)1719-1724
Number of pages6
JournalCritical Care Medicine
Volume34
Issue number6
DOIs
StatePublished - Jun 2006

Fingerprint

Inhalation Burns
Albuterol
Acute Lung Injury
Smoke
Smoke Inhalation Injury
Sheep
Lung
Weights and Measures
Tracheostomy
Body Surface Area
Lymph
Pulmonary Edema
Airway Obstruction
Burns
Resuscitation
Anti-Inflammatory Agents
Asthma
Animal Models
Inflammation
Pressure

Keywords

  • Acute lung injury
  • Airway obstruction
  • Alveolar epithelium
  • Beta agonists
  • Burns
  • Gas exchange
  • Inhalation injury

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Continuous nebulized albuterol attenuates acute lung injury in an ovine model of combined burn and smoke inhalation. / Palmieri, Tina L.; Enkhbaatar, Perenlei; Bayliss, Robert; Traber, Lillian D.; Cox, Robert A.; Hawkins, Hal K.; Herndon, David; Greenhalgh, David G.; Traber, Daniel L.

In: Critical Care Medicine, Vol. 34, No. 6, 06.2006, p. 1719-1724.

Research output: Contribution to journalArticle

Palmieri, TL, Enkhbaatar, P, Bayliss, R, Traber, LD, Cox, RA, Hawkins, HK, Herndon, D, Greenhalgh, DG & Traber, DL 2006, 'Continuous nebulized albuterol attenuates acute lung injury in an ovine model of combined burn and smoke inhalation', Critical Care Medicine, vol. 34, no. 6, pp. 1719-1724. https://doi.org/10.1097/01.CCM.0000217215.82821.C5
Palmieri, Tina L. ; Enkhbaatar, Perenlei ; Bayliss, Robert ; Traber, Lillian D. ; Cox, Robert A. ; Hawkins, Hal K. ; Herndon, David ; Greenhalgh, David G. ; Traber, Daniel L. / Continuous nebulized albuterol attenuates acute lung injury in an ovine model of combined burn and smoke inhalation. In: Critical Care Medicine. 2006 ; Vol. 34, No. 6. pp. 1719-1724.
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AU - Palmieri, Tina L.

AU - Enkhbaatar, Perenlei

AU - Bayliss, Robert

AU - Traber, Lillian D.

AU - Cox, Robert A.

AU - Hawkins, Hal K.

AU - Herndon, David

AU - Greenhalgh, David G.

AU - Traber, Daniel L.

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KW - Acute lung injury

KW - Airway obstruction

KW - Alveolar epithelium

KW - Beta agonists

KW - Burns

KW - Gas exchange

KW - Inhalation injury

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