Continuous, noninvasive monitoring of total hemoglobin concentration by an optoacoustic technique

Rinat Esenaliev, Yuriy Y. Petrov, Olaf Hartrumpf, Donald J. Deyo, Donald Prough

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Measurement of total hemoglobin concentration [Hgb] is a blood test that is widely used to evaluate outpatients, hospital inpatients, and surgical patients, especially those undergoing surgery associated with extensive blood loss, rapid fluid administration, and transfusion of packed red blood cells. Current techniques for measurement of [Hgb] are invasive (requiring blood sampling) and cannot provide real-time, continuous monitoring. We propose to use an optoacoustic technique for noninvasive and continuous monitoring of [Hgb]. The high resolution of the optoacoustic technique may provide accurate measurement of [Hgb] by detection and analysis of optoacoustic signals induced by short optical pulses in blood circulating in arteries or veins. We designed, built, and tested in vitro (in both tissue phantoms and in preliminary in vivo experiments) a portable optoacoustic system for the monitoring of [Hgb] in the radial artery. The system includes a nanosecond laser operating in the near-infrared spectral range and a sensitive optoacoustic probe designed to irradiate the radial artery through the skin and detect optoacoustic signals induced in blood. Results of our studies demonstrated that (1) the slope of optoacoustic waves induced in blood in the transmission mode is linearly dependent on [Hgb] in the range from 6.2 to 12.4 g/dl, (2) optoacoustic signals can be detected despite optical attenuation in turbid tissue phantoms with a thickness of 1 cm, and (3) the optoacoustic system detects signals induced in blood circulating in the radial artery. These data suggest that the optoacoustic system can be used for accurate, noninvasive, real-time, and continuous monitoring of [Hgb].

Original languageEnglish (US)
Pages (from-to)3401-3407
Number of pages7
JournalApplied Optics
Volume43
Issue number17
DOIs
StatePublished - Jun 10 2004

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Photoacoustic effect
Hemoglobin
hemoglobin
blood
Blood
arteries
Monitoring
transfusion
erythrocytes
veins
Tissue
surgery
Signal systems
attenuation
sampling
slopes
Surgery
Laser pulses
Skin
probes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Continuous, noninvasive monitoring of total hemoglobin concentration by an optoacoustic technique. / Esenaliev, Rinat; Petrov, Yuriy Y.; Hartrumpf, Olaf; Deyo, Donald J.; Prough, Donald.

In: Applied Optics, Vol. 43, No. 17, 10.06.2004, p. 3401-3407.

Research output: Contribution to journalArticle

Esenaliev, Rinat ; Petrov, Yuriy Y. ; Hartrumpf, Olaf ; Deyo, Donald J. ; Prough, Donald. / Continuous, noninvasive monitoring of total hemoglobin concentration by an optoacoustic technique. In: Applied Optics. 2004 ; Vol. 43, No. 17. pp. 3401-3407.
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