Continuous renal replacement therapy amino acid, trace metal and folate clearance in critically ill children

Michael Zappitelli, Marisa Juarez, Leticia Castillo, Jorge Coss-Bu, Stuart L. Goldstein

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Purpose: We hypothesized continuous veno-venous hemodialysis (CVVHD) amino acid, trace metals and folate clearance impacts nutrient balance. Methods: Critically ill children receiving CVVHD were studied prospectively for 5 days. Blood concentrations (amino acids, copper, zinc, manganese, chromium, selenium and folate) were measured at CVVHD initiation, and Days 2 and 5. CVVHD clearance, losses and nutrient balances were calculated on Days 2 and 5. Results: We studied 15 children aged 7.7 ± 6.7 years. Nitrogen balance was negative on Days 2 and 5. Amino acid clearances ranged from 2.8 to 51.1 ml/min per 1.73 m2. CVVHD losses corresponded to 20% of intake. Days 2 and 5 balances were negative for selenium, but positive for other trace metals. Folate clearance was 16 ml/min per 1.73 m2 on Days 2 and 5 and serum concentrations decreased significantly from initiation to Day 5 (P < 0.05). Conclusions: Nutrient losses by CVHHD may impact adequate nutrition provision.

Original languageEnglish (US)
Pages (from-to)698-706
Number of pages9
JournalIntensive Care Medicine
Volume35
Issue number4
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

Fingerprint

Renal Replacement Therapy
Folic Acid
Critical Illness
Renal Dialysis
Metals
Amino Acids
Selenium
Food
Chromium
Manganese
Zinc
Copper
Nitrogen
Serum

Keywords

  • Continuous veno-venous hemodialysis
  • Intensive care
  • Nutrition
  • Pediatric
  • Protein
  • Vitamins

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Continuous renal replacement therapy amino acid, trace metal and folate clearance in critically ill children. / Zappitelli, Michael; Juarez, Marisa; Castillo, Leticia; Coss-Bu, Jorge; Goldstein, Stuart L.

In: Intensive Care Medicine, Vol. 35, No. 4, 01.04.2009, p. 698-706.

Research output: Contribution to journalArticle

Zappitelli, Michael ; Juarez, Marisa ; Castillo, Leticia ; Coss-Bu, Jorge ; Goldstein, Stuart L. / Continuous renal replacement therapy amino acid, trace metal and folate clearance in critically ill children. In: Intensive Care Medicine. 2009 ; Vol. 35, No. 4. pp. 698-706.
@article{45ae921201f64fe29dd62bcbd9c3d1d5,
title = "Continuous renal replacement therapy amino acid, trace metal and folate clearance in critically ill children",
abstract = "Purpose: We hypothesized continuous veno-venous hemodialysis (CVVHD) amino acid, trace metals and folate clearance impacts nutrient balance. Methods: Critically ill children receiving CVVHD were studied prospectively for 5 days. Blood concentrations (amino acids, copper, zinc, manganese, chromium, selenium and folate) were measured at CVVHD initiation, and Days 2 and 5. CVVHD clearance, losses and nutrient balances were calculated on Days 2 and 5. Results: We studied 15 children aged 7.7 ± 6.7 years. Nitrogen balance was negative on Days 2 and 5. Amino acid clearances ranged from 2.8 to 51.1 ml/min per 1.73 m2. CVVHD losses corresponded to 20{\%} of intake. Days 2 and 5 balances were negative for selenium, but positive for other trace metals. Folate clearance was 16 ml/min per 1.73 m2 on Days 2 and 5 and serum concentrations decreased significantly from initiation to Day 5 (P < 0.05). Conclusions: Nutrient losses by CVHHD may impact adequate nutrition provision.",
keywords = "Continuous veno-venous hemodialysis, Intensive care, Nutrition, Pediatric, Protein, Vitamins",
author = "Michael Zappitelli and Marisa Juarez and Leticia Castillo and Jorge Coss-Bu and Goldstein, {Stuart L.}",
year = "2009",
month = "4",
day = "1",
doi = "10.1007/s00134-009-1420-9",
language = "English (US)",
volume = "35",
pages = "698--706",
journal = "Intensive Care Medicine",
issn = "0342-4642",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Continuous renal replacement therapy amino acid, trace metal and folate clearance in critically ill children

AU - Zappitelli, Michael

AU - Juarez, Marisa

AU - Castillo, Leticia

AU - Coss-Bu, Jorge

AU - Goldstein, Stuart L.

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Purpose: We hypothesized continuous veno-venous hemodialysis (CVVHD) amino acid, trace metals and folate clearance impacts nutrient balance. Methods: Critically ill children receiving CVVHD were studied prospectively for 5 days. Blood concentrations (amino acids, copper, zinc, manganese, chromium, selenium and folate) were measured at CVVHD initiation, and Days 2 and 5. CVVHD clearance, losses and nutrient balances were calculated on Days 2 and 5. Results: We studied 15 children aged 7.7 ± 6.7 years. Nitrogen balance was negative on Days 2 and 5. Amino acid clearances ranged from 2.8 to 51.1 ml/min per 1.73 m2. CVVHD losses corresponded to 20% of intake. Days 2 and 5 balances were negative for selenium, but positive for other trace metals. Folate clearance was 16 ml/min per 1.73 m2 on Days 2 and 5 and serum concentrations decreased significantly from initiation to Day 5 (P < 0.05). Conclusions: Nutrient losses by CVHHD may impact adequate nutrition provision.

AB - Purpose: We hypothesized continuous veno-venous hemodialysis (CVVHD) amino acid, trace metals and folate clearance impacts nutrient balance. Methods: Critically ill children receiving CVVHD were studied prospectively for 5 days. Blood concentrations (amino acids, copper, zinc, manganese, chromium, selenium and folate) were measured at CVVHD initiation, and Days 2 and 5. CVVHD clearance, losses and nutrient balances were calculated on Days 2 and 5. Results: We studied 15 children aged 7.7 ± 6.7 years. Nitrogen balance was negative on Days 2 and 5. Amino acid clearances ranged from 2.8 to 51.1 ml/min per 1.73 m2. CVVHD losses corresponded to 20% of intake. Days 2 and 5 balances were negative for selenium, but positive for other trace metals. Folate clearance was 16 ml/min per 1.73 m2 on Days 2 and 5 and serum concentrations decreased significantly from initiation to Day 5 (P < 0.05). Conclusions: Nutrient losses by CVHHD may impact adequate nutrition provision.

KW - Continuous veno-venous hemodialysis

KW - Intensive care

KW - Nutrition

KW - Pediatric

KW - Protein

KW - Vitamins

UR - http://www.scopus.com/inward/record.url?scp=62949131344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62949131344&partnerID=8YFLogxK

U2 - 10.1007/s00134-009-1420-9

DO - 10.1007/s00134-009-1420-9

M3 - Article

C2 - 19183946

AN - SCOPUS:62949131344

VL - 35

SP - 698

EP - 706

JO - Intensive Care Medicine

JF - Intensive Care Medicine

SN - 0342-4642

IS - 4

ER -