Contractile mechanisms of gallbladder filling and emptying in dogs

Hiroyoshi Abiru, Sushil K. Sarna, Robert E. Condon

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background/Aims: The mechanisms of gallbladder filling and emptying during the fasting state, postprandial state, and after intravenous administration of cholecystokinin, motilin, and morphine were investigated in conscious dogs. Methods: Bile flow in the cystic and common bile ducts was measured by miniature flow probes. Results: The gallbladder showed brief alternating excursions of filling and emptying in the fasting and fed state. The emptying excursions exceeded the filling excursions during phase II and for about 4 hours after a meal. The filling excursions exceeded the emptying excursions during phase I, phase III, and the latter half of the postprandial state. Most gallbladder emptying occurred when its pressure was high, and most filling occurred when its pressure was low. The duodenal contractions played a major role in gallbladder filling and emptying during phase III. Conclusions: Gallbladder filling and emptying are not monotonous during the fasting and postprandial states. The brief alternating excursions of filling and emptying would almost continually mix the concentrated gallbladder bile with the fresh dilute hepatic bile to prevent supersaturation of the gallbladder bile during the fasting state and extend the delivery of a small volume of concentrated gallbladder bile for a period of several hours after a meal.

Original languageEnglish (US)
Pages (from-to)1652-1661
Number of pages10
JournalGastroenterology
Volume106
Issue number6
StatePublished - 1994
Externally publishedYes

Fingerprint

Gallbladder Emptying
Bile
Gallbladder
Dogs
Fasting
Meals
Motilin
Pressure
Cholecystokinin
Common Bile Duct
Intravenous Administration
Morphine
Liver

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Abiru, H., Sarna, S. K., & Condon, R. E. (1994). Contractile mechanisms of gallbladder filling and emptying in dogs. Gastroenterology, 106(6), 1652-1661.

Contractile mechanisms of gallbladder filling and emptying in dogs. / Abiru, Hiroyoshi; Sarna, Sushil K.; Condon, Robert E.

In: Gastroenterology, Vol. 106, No. 6, 1994, p. 1652-1661.

Research output: Contribution to journalArticle

Abiru, H, Sarna, SK & Condon, RE 1994, 'Contractile mechanisms of gallbladder filling and emptying in dogs', Gastroenterology, vol. 106, no. 6, pp. 1652-1661.
Abiru H, Sarna SK, Condon RE. Contractile mechanisms of gallbladder filling and emptying in dogs. Gastroenterology. 1994;106(6):1652-1661.
Abiru, Hiroyoshi ; Sarna, Sushil K. ; Condon, Robert E. / Contractile mechanisms of gallbladder filling and emptying in dogs. In: Gastroenterology. 1994 ; Vol. 106, No. 6. pp. 1652-1661.
@article{f9cc745970e44eb787d25e2cfcb1b937,
title = "Contractile mechanisms of gallbladder filling and emptying in dogs",
abstract = "Background/Aims: The mechanisms of gallbladder filling and emptying during the fasting state, postprandial state, and after intravenous administration of cholecystokinin, motilin, and morphine were investigated in conscious dogs. Methods: Bile flow in the cystic and common bile ducts was measured by miniature flow probes. Results: The gallbladder showed brief alternating excursions of filling and emptying in the fasting and fed state. The emptying excursions exceeded the filling excursions during phase II and for about 4 hours after a meal. The filling excursions exceeded the emptying excursions during phase I, phase III, and the latter half of the postprandial state. Most gallbladder emptying occurred when its pressure was high, and most filling occurred when its pressure was low. The duodenal contractions played a major role in gallbladder filling and emptying during phase III. Conclusions: Gallbladder filling and emptying are not monotonous during the fasting and postprandial states. The brief alternating excursions of filling and emptying would almost continually mix the concentrated gallbladder bile with the fresh dilute hepatic bile to prevent supersaturation of the gallbladder bile during the fasting state and extend the delivery of a small volume of concentrated gallbladder bile for a period of several hours after a meal.",
author = "Hiroyoshi Abiru and Sarna, {Sushil K.} and Condon, {Robert E.}",
year = "1994",
language = "English (US)",
volume = "106",
pages = "1652--1661",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Contractile mechanisms of gallbladder filling and emptying in dogs

AU - Abiru, Hiroyoshi

AU - Sarna, Sushil K.

AU - Condon, Robert E.

PY - 1994

Y1 - 1994

N2 - Background/Aims: The mechanisms of gallbladder filling and emptying during the fasting state, postprandial state, and after intravenous administration of cholecystokinin, motilin, and morphine were investigated in conscious dogs. Methods: Bile flow in the cystic and common bile ducts was measured by miniature flow probes. Results: The gallbladder showed brief alternating excursions of filling and emptying in the fasting and fed state. The emptying excursions exceeded the filling excursions during phase II and for about 4 hours after a meal. The filling excursions exceeded the emptying excursions during phase I, phase III, and the latter half of the postprandial state. Most gallbladder emptying occurred when its pressure was high, and most filling occurred when its pressure was low. The duodenal contractions played a major role in gallbladder filling and emptying during phase III. Conclusions: Gallbladder filling and emptying are not monotonous during the fasting and postprandial states. The brief alternating excursions of filling and emptying would almost continually mix the concentrated gallbladder bile with the fresh dilute hepatic bile to prevent supersaturation of the gallbladder bile during the fasting state and extend the delivery of a small volume of concentrated gallbladder bile for a period of several hours after a meal.

AB - Background/Aims: The mechanisms of gallbladder filling and emptying during the fasting state, postprandial state, and after intravenous administration of cholecystokinin, motilin, and morphine were investigated in conscious dogs. Methods: Bile flow in the cystic and common bile ducts was measured by miniature flow probes. Results: The gallbladder showed brief alternating excursions of filling and emptying in the fasting and fed state. The emptying excursions exceeded the filling excursions during phase II and for about 4 hours after a meal. The filling excursions exceeded the emptying excursions during phase I, phase III, and the latter half of the postprandial state. Most gallbladder emptying occurred when its pressure was high, and most filling occurred when its pressure was low. The duodenal contractions played a major role in gallbladder filling and emptying during phase III. Conclusions: Gallbladder filling and emptying are not monotonous during the fasting and postprandial states. The brief alternating excursions of filling and emptying would almost continually mix the concentrated gallbladder bile with the fresh dilute hepatic bile to prevent supersaturation of the gallbladder bile during the fasting state and extend the delivery of a small volume of concentrated gallbladder bile for a period of several hours after a meal.

UR - http://www.scopus.com/inward/record.url?scp=0028228834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028228834&partnerID=8YFLogxK

M3 - Article

C2 - 8194713

AN - SCOPUS:0028228834

VL - 106

SP - 1652

EP - 1661

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 6

ER -