Contractile tail machines of bacteriophages

Petr Leiman, Mikhail M. Shneider

Research output: Chapter in Book/Report/Conference proceedingChapter

104 Citations (Scopus)

Abstract

Bacteriophages with contractile tails epitomize the concepts of "virus" and "phage" for many because the tails of these phages undergo a large conformational change - resembling the action of a syringe - upon the attachment to the host cell. The contractile tails belong to the recently recognized class of "contractile systems," which includes phage tails, their close relatives R-type pyocins, the bacterial type VI secretion system, and the virulence cassette of Photorhabdus. Their function is to deliver large proteins and/or DNA into the cytoplasm of a bacterial or eukaryotic cell. The structure of the core components of all contractile tail-like systems is conserved, but the corresponding genes have diverged to such a degree that the common ancestry can no longer be easily detected at the level of amino acid sequence. At present, it is unclear, whether the contractile systems originated in bacteria or in phages. This chapter describes the structure and function of phage contractile tails and compares them with other phage tails and with other known contractile systems.

Original languageEnglish (US)
Title of host publicationViral Molecular Machines
Pages93-114
Number of pages22
Volume726
DOIs
StatePublished - 2012
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume726
ISSN (Print)00652598

Fingerprint

Bacteriophages
Pyocins
Photorhabdus
Syringes
Eukaryotic Cells
Viruses
Virulence
Amino Acid Sequence
Bacteria
Cytoplasm
Genes
Amino Acids
DNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Leiman, P., & Shneider, M. M. (2012). Contractile tail machines of bacteriophages. In Viral Molecular Machines (Vol. 726, pp. 93-114). (Advances in Experimental Medicine and Biology; Vol. 726). https://doi.org/10.1007/978-1-4614-0980-9_5

Contractile tail machines of bacteriophages. / Leiman, Petr; Shneider, Mikhail M.

Viral Molecular Machines. Vol. 726 2012. p. 93-114 (Advances in Experimental Medicine and Biology; Vol. 726).

Research output: Chapter in Book/Report/Conference proceedingChapter

Leiman, P & Shneider, MM 2012, Contractile tail machines of bacteriophages. in Viral Molecular Machines. vol. 726, Advances in Experimental Medicine and Biology, vol. 726, pp. 93-114. https://doi.org/10.1007/978-1-4614-0980-9_5
Leiman P, Shneider MM. Contractile tail machines of bacteriophages. In Viral Molecular Machines. Vol. 726. 2012. p. 93-114. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-0980-9_5
Leiman, Petr ; Shneider, Mikhail M. / Contractile tail machines of bacteriophages. Viral Molecular Machines. Vol. 726 2012. pp. 93-114 (Advances in Experimental Medicine and Biology).
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