Contrast Sonography, Video Densitometry and Intervillous Blood Flow

A Pilot Project

W. H. Barth, D. C. McCurnin, K. Dee Carey, Gary Hankins

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: To examine the feasibility of constructing time-intensity (TI) curves from the intervillous space with an intravascular ultrasound contrast agent and computer assisted video densitometry. Study design: We sedated nine pregnant baboons, optimized the grey scale and color Doppler images of their placentas, and then fixed the transducers in place. For each injection of contrast, we recorded images on videotape without changing the ultrasound image processing functions. Video images were captured using a Macintosh personal computer equipped with a video-capture board using image analysis software (Image 1.4, W Rasband, NIH). For each injection, we sampled digitized images of a fixed region of interest at regular intervals. After computing the mean video density of each image, we used the sampling frequency to construct TI curves depicting any change over time as the contrast agents washed into and out of the intervillous space. Results: Three of four agents tested produced changes in the video density of the placenta. TI curves were established using both grey scale and color Doppler signal augmentation. As expected, intra-arterial agents produced rapid accumulation and decay. Intravenous agents produced more protracted effects secondary to bolus dilution and transit through the right heart and pulmonary vascular bed. Conclusion: TI curves may be generated from the intervillous space with the use of a transpulmonary ultrasound contrast agent and video densitometry. If validated by further study, this may allow investigators to apply ultrasound and indicator-dilution theory to intervillous blood flow.

Original languageEnglish (US)
Pages (from-to)719-726
Number of pages8
JournalPlacenta
Volume27
Issue number6-7
DOIs
StatePublished - Jun 2006

Fingerprint

Densitometry
Ultrasonography
Contrast Media
Placenta
Color
Injections
Videotape Recording
Papio
Microcomputers
Transducers
Blood Vessels
Software
Research Personnel
Lung

Keywords

  • Contrast sonography
  • Intervillous blood flow
  • Ultrasound contrast
  • Uteroplacental blood flow

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Contrast Sonography, Video Densitometry and Intervillous Blood Flow : A Pilot Project. / Barth, W. H.; McCurnin, D. C.; Dee Carey, K.; Hankins, Gary.

In: Placenta, Vol. 27, No. 6-7, 06.2006, p. 719-726.

Research output: Contribution to journalArticle

Barth, WH, McCurnin, DC, Dee Carey, K & Hankins, G 2006, 'Contrast Sonography, Video Densitometry and Intervillous Blood Flow: A Pilot Project', Placenta, vol. 27, no. 6-7, pp. 719-726. https://doi.org/10.1016/j.placenta.2005.07.007
Barth, W. H. ; McCurnin, D. C. ; Dee Carey, K. ; Hankins, Gary. / Contrast Sonography, Video Densitometry and Intervillous Blood Flow : A Pilot Project. In: Placenta. 2006 ; Vol. 27, No. 6-7. pp. 719-726.
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