Control of postganglionic sympathetic efferent fibers by neurokinin 1 receptors in rats

Richard E. Coggeshall, Susan M. Carlton

Research output: Contribution to journalArticle


Substance P (SP) is released peripherally from nociceptive terminals and has a direct effect on vascular cells. The present study suggests an indirect effect as well. In normal rats and rats with one hindpaw inflamed for 48 h following intraplantar injection of complete Freund's adjuvant, neurokinin 1 (NK1) receptors were immunohistochemically localized on postganglionic sympathetic axons. The percentage of NK1-labeled axons in the gray rami from normal rats was 35.0±5.0; in inflamed rats this percentage increased significantly to 49.1±2.3. These data suggest a sensory-sympathetic reflex, where SP activates these peripheral sympathetic receptors with subsequent release of noradrenaline and other compounds to affect vascular cells indirectly. This control is enhanced after inflammation.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalNeuroscience Letters
Issue number3
StatePublished - Dec 26 2003



  • Inflammation
  • Pain
  • Sensory
  • Substance P

ASJC Scopus subject areas

  • Neuroscience(all)

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